TCI B6761 4-Benzylmorpholine is a heterocyclic building block consisting of a morpholine ring N-substituted with a benzyl group. Its tertiary amine character allows it to act as a mild organic base, an amine additive in catalytic systems, and a convenient intermediate in multi-step synthesis. The benzyl group can be removed by hydrogenolysis, making the compound a useful model substrate for protecting-group studies, while the morpholine core itself appears widely in pharmaceutical scaffolds. AMI Scientific supplies this TCI reagent in two bench-scale sizes; handle it in a fume hood and keep the container tightly closed.
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- Reddy et al. (2019). Synthesis of (R)-2-benzylmorpholine employing catalytic stereospecific rearrangement of L-Phenylalaninol. Letters in Organic Chemistry doi:10.2174/1570178615666181105110940
- D'Arrigo et al. (1998). Chemo-enzymatic synthesis of the active enantiomer of the anorressant 2-benzylmorpholine. Tetrahedron: Asymmetry doi:10.1016/s0957-4166(98)00432-7
- Rosenau et al. (2005). On the non-classical course of Polonowski reactions of N-benzylmorpholine-N-oxide (NBnMO). Tetrahedron doi:10.1016/j.tet.2005.02.001
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