Biotin-PEG4-Amine TCI B5560

Chemical Identity

Other names: N-Biotinyl-3,6,9,12-tetraoxatetradecane-1,14-diamine · N-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]biotinamide
CAS No.: 663171-32-2
PubChem: CID 77078240·SID 354335514
Formula: C20H38N4O6S
Molecular weight: 462.61 g/mol
Purity: >94.0%(HPLC)
Storage: <0°C

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl]pentanamide
SMILES: C1C2C(C(S1)CCCCC(=O)NCCOCCOCCOCCOCCN)NC(=O)N2
InChIKey: GVGZXRGPGZMYTB-LNLFQRSKSA-N
MDL: MDL26142992

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Biotin-PEG4-Amine (TCI B5560, CAS 663171-32-2) is a high-purity bioconjugation reagent featuring a biotin moiety linked via a PEG4 spacer to a reactive primary amine group, enabling efficient labeling of biomolecules such as proteins, peptides, and nucleic acids. This compound facilitates covalent attachment of biotin through standard coupling chemistries, making it suitable for avidin/streptavidin-based detection, purification, and immobilization workflows. Widely employed in chemical biology, drug discovery, and biosensor development, it serves as a versatile building block for constructing biotinylated conjugates with enhanced solubility and reduced steric hindrance.