7-Chloroquinoline TCI C3085

Name: TCI C3085 612-61-3 7-Chloroquinoline
Brand: TCI
SKU: TCI2510C308518032
Price: 3807300.0 IDR
Availability: InStock

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Berat 5g 25g

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Description

TCI C3085 7-Chloroquinoline is an aromatic heterocyclic compound belonging to the quinoline family, a bicyclic framework formed by the fusion of a benzene ring with a pyridine ring. As a heterocyclic building block, it supplies a nitrogen-rich aromatic core that appears very frequently in bioactive molecules, coordination ligands, and functional materials. The chlorine atom at the seventh position provides an additional handle for downstream reactions while simultaneously modulating the electron distribution across the entire ring system. In a synthesis laboratory, having a pre-substituted quinoline core on hand removes several ring-forming steps that would otherwise demand harsh reaction conditions and long working hours.

The properties that make this compound a preferred choice lie in the combination of a weakly basic pyridinic nitrogen with a stable, broadly delocalised aromatic system. The nitrogen atom can coordinate to transition metal ions, be oxidised to the corresponding N-oxide in order to activate specific positions, or be quaternised to form quinolinium salts. Meanwhile, the aromatic chlorine atom can act as a leaving group in nucleophilic aromatic substitution and as a reactive site for further transformation. This dual reactivity, held within one rigid and planar scaffold, gives chemists a predictable starting point from which several different synthetic routes can be developed without redesigning the core structure.

In Indonesian laboratories, 7-chloroquinoline is typically encountered in organic synthesis and medicinal chemistry groups at universities and research institutes, as well as in industrial R&D units working on heterocyclic intermediates. It is commonly used at bench scale for route development, undergraduate and postgraduate thesis work, and method exploration, where a well-defined substituted quinoline shortens the path to a target molecule. Its role is usually that of a starting material or intermediate rather than a finished product.

Laboratory Applications

Nucleophilic aromatic substitution studies — the aromatic chlorine serves as a leaving group, allowing amines, alkoxides, and thiolates to be installed directly onto the quinoline ring under controlled conditions.
Medicinal chemistry scaffold construction — the quinoline core is a recurring motif in bioactive molecules, so this substituted building block shortens the route from starting material to candidate structure.
Coordination chemistry and ligand preparation — the pyridinic nitrogen coordinates transition metal ions, making the compound a practical precursor for metal complexes and ligand frameworks in research settings.
N-oxide and quinolinium salt chemistry — the nitrogen atom can be oxidised to the N-oxide to activate particular ring positions, or quaternised to give quinolinium salts.
Functional materials research — the stable, broadly delocalised aromatic system provides a rigid nitrogen-containing core suitable for exploratory work on functional and electronically active organic materials.

Specifications

Brand: TCI
CAS number: 612-61-3
Chemical name: 7-Chloroquinoline
Product code: C3085
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Storage: store in a tightly closed container, protected from light and moisture, following the manufacturer's stated conditions on the label and safety data sheet

Handling and Storage

Store 7-chloroquinoline in its original tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials. Amber glass or the supplier's original packaging is suitable for maintaining product quality, and containers should be resealed promptly after each use to limit exposure to air and moisture. Handle the compound inside a fume hood using appropriate personal protective equipment, including gloves, safety goggles, and a laboratory coat. Avoid inhalation of dust or vapour and direct contact with skin and eyes. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials in accordance with applicable chemical waste procedures.