TCI D1293 N,N-Dimethylformamide Dimethyl Acetal, commonly abbreviated as DMF-DMA, is a versatile organic synthesis reagent built on a formamide framework bearing two methoxy groups on the acetal carbon atom. It belongs to the family of non-heterocyclic building blocks and is widely recognised as a key reagent for introducing a one-carbon unit into a target molecule. In synthetic laboratories, DMF-DMA is highly valued for its ability to convert compounds containing active hydrogen into enaminones or amidines — intermediates that serve as gateways to the construction of the many heterocyclic ring systems that matter in medicinal chemistry.
The properties that make this reagent such a frequent choice are its high yet well-directed reactivity, together with the ease of using it without requiring a complicated catalyst system. DMF-DMA acts both as a source of the dimethylaminomethylene group and as a mild methylating agent for carboxylic acid functionalities, so a single reagent can serve several distinct classes of transformation. This dual capability simplifies reagent inventories and shortens route planning, since one bottle covers formylation-equivalent chemistry, amidine formation and gentle ester preparation within the same workflow.
The reagent is supplied as a liquid that is highly sensitive to moisture; contact with water hydrolyses it and reduces reaction effectiveness. For this reason, the quality of the results obtained depends strongly on moisture-free handling technique. In Indonesian laboratories this makes DMF-DMA a reagent typically reserved for synthetic and medicinal chemistry groups equipped for anhydrous work, where it is dispensed under inert conditions in university research laboratories, pharmaceutical R&D units and contract synthesis facilities carrying out heterocycle construction.
- Enaminone synthesis — DMF-DMA converts substrates bearing active methylene or active hydrogen centres into enaminones cleanly, giving reliable access to versatile intermediates without complicated catalyst systems.
- Heterocyclic ring construction — the enaminone and amidine intermediates generated by this reagent act as direct precursors to the many heterocyclic scaffolds required throughout medicinal chemistry programmes.
- Amidine formation — the reagent transfers its dimethylaminomethylene unit to suitable nitrogen-containing substrates, delivering amidine products through a single, well-directed and readily controlled transformation step.
- One-carbon unit introduction — DMF-DMA serves as a dependable source of a single carbon atom for building block elaboration, extending molecular frameworks in non-heterocyclic building block chemistry.
- Mild esterification of carboxylic acids — acting as a gentle methylating agent, the reagent converts carboxylic acid groups without the harsh conditions that more aggressive methylating reagents demand.
| Brand | TCI |
|---|---|
| CAS number | 4637-24-5 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | available in the standard TCI catalogue pack sizes for this item |
| Physical form | liquid |
| Storage | highly moisture sensitive; store under strictly anhydrous conditions |
- Product code: D1293
Store the reagent in its original tightly sealed container, kept in a cool, dry and well-ventilated area away from sources of ignition and from any incompatible materials. Because DMF-DMA hydrolyses on contact with water, the container should be protected from atmospheric moisture at all times; an inert gas blanket and a desiccated storage cabinet are appropriate. Dispense using dry glassware and dry syringe or cannula technique, and reseal immediately after use to limit air ingress. Handle inside a functioning fume hood while wearing safety glasses, chemically resistant gloves and a laboratory coat. Consult the manufacturer's safety data sheet before first use and follow institutional waste disposal procedures.
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