N,N-Dimethylformamide Diethyl Acetal [for Esterification] TCI D1294

Chemical Identity

Other names: 1,1-Diethoxytrimethylamine
CAS No.: 1188-33-6
PubChem: CID 70913·SID 87567821
Formula: C7H17NO2
Molecular weight: 147.22 g/mol
Purity: >95.0%(GC)
Reference databases: ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1,1-diethoxy-N,N-dimethylmethanamine
SMILES: CCOC(N(C)C)OCC
InChIKey: BWKAYBPLDRWMCJ-UHFFFAOYSA-N
MDL: MDL00009227

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TCI D1294 N,N-Dimethylformamide Diethyl Acetal [for Esterification] is an organic synthesis reagent from the formamide acetal family, formulated specifically for esterification work. The reagent supplies an ethyl group, allowing carboxylic acids to be converted into their corresponding ethyl esters without a strong acid catalyst and without prolonged reflux in an excess of alcohol. As a non-heterocyclic building block, it holds an important position in both synthesis and analytical laboratories, because it shortens the working sequence and reduces the risk of damaging other sensitive functional groups present on the target molecule.

The principal advantage of this reagent lies in its mild, essentially neutral reaction conditions. Substrates carrying acid-labile groups, additional ester linkages, or stereogenic centres can therefore be processed with a lower risk of racemisation and decomposition than would be expected under classical acid-catalysed esterification. Beyond esterification, the formamide acetal framework is also able to react with active methylene compounds to form enaminone derivatives, although the product's primary intended use is genuinely directed towards esterification reactions. It is supplied as a moisture-sensitive liquid, so the best results are obtained only when the reagent is handled and stored correctly.

In Indonesian laboratories, this reagent is typically used in university and institutional research groups working on organic synthesis, in medicinal and natural-product chemistry projects where sensitive intermediates must be esterified, and in analytical laboratories that prepare ester derivatives prior to instrumental measurement. Because it removes the need for strongly acidic conditions and extended reflux, it fits well into routine bench workflows where sample quantities are limited and functional-group integrity has to be preserved.

Advantages (TCI brochure)

Liquid at room temperature and easy to handle
Stable at room temperature when stored away from moisture

TCI brochures (PDF)

GC Derivatization Reagents 2026-03-25 · p. 4
Alkylation Reagents for Ester Synthesis 2026-04-06 · p. 3

Related TCI products

Ethyl ester preparation from carboxylic acids: supplies the ethyl group directly, so conversion proceeds without a strong acid catalyst or a large excess of ethanol under prolonged reflux.
Esterification of acid-sensitive substrates: the mild, nearly neutral conditions allow molecules bearing acid-labile protecting groups or additional ester linkages to be converted with reduced decomposition.
Derivatisation of stereogenic compounds: because harsh acidic media are avoided, substrates containing stereogenic centres can be esterified with a lower risk of racemisation during the reaction.
Enaminone synthesis from active methylene compounds: the formamide acetal framework reacts with active methylene substrates to build enaminone derivatives useful as intermediates in further synthetic sequences.
Sample derivatisation in analytical laboratories: forming ester derivatives shortens the preparation sequence and helps preserve other sensitive functional groups on the analyte before instrumental analysis.

From the TCI brochure

Esterification reagent for fatty acids giving alkyl esters
Conversion of amino acids into N-dimethylaminomethylene-O-alkyl esters in one step

Brand	TCI
CAS number	1188-33-6
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	available in the pack sizes offered for this catalogue item
Physical form	liquid, moisture sensitive
Storage	keep tightly closed and protected from moisture

Product designation: D1294, N,N-Dimethylformamide Diethyl Acetal [for Esterification]

Because this reagent is a moisture-sensitive liquid, it should be stored in a tightly closed original container and protected from atmospheric humidity; best results are obtained only when the reagent is kept dry. Store in a cool, well-ventilated area away from heat, ignition sources, and incompatible materials, and keep the container closed when not in use. Dispense in a fume hood using dry glassware and dry syringes or cannulas, and minimise the time the container remains open. Wear safety glasses, chemical-resistant gloves, and a laboratory coat while handling. Return the container to storage promptly after use and follow the manufacturer's safety data sheet together with local laboratory waste-disposal procedures.

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