5'-Deoxy-5-fluorouridine TCI D3579

Name: TCI D3579 3094-09-5 5'-Deoxy-5-fluorouridine
Brand: TCI
SKU: TCI2510D357923895
Price: 2333100.0 IDR
Availability: InStock

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Berat 1g 5g

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Description

TCI D3579 5'-Deoxy-5-fluorouridine, widely known as doxifluridine or 5'-DFUR, is a synthetic fluoropyrimidine nucleoside that holds an important position as a reference material in biochemistry and pharmacology laboratories. The compound is a uridine derivative that lacks the hydroxyl group at the 5' position and carries a fluorine atom at position 5 of the pyrimidine ring. This distinctive structure makes it a classic prodrug studied intensively in antimetabolite metabolism research, because its conversion into the active form depends on thymidine phosphorylase activity within tissues. In the laboratory, this material serves as a test compound, an analytical standard, and a starting material for mechanistic studies of fluoropyrimidine-based drugs.

The characteristics that lead many researchers to select 5'-Deoxy-5-fluorouridine are the combination of reasonable storage stability in solid form and highly specific biological reactivity once it is enzymatically activated. The presence of the fluorine atom at position 5 gives the molecule electronic properties different from those of natural uracil, allowing the compound to interfere with the thymidylate synthesis pathway after conversion. Its well-defined structure and consistent behaviour as a nucleoside derivative make it suitable for use as a comparison compound, so that experimental results obtained in different laboratories remain interpretable against a common reference point.

In Indonesian laboratories, this material is typically used in university research groups, pharmacology and biochemistry teaching laboratories, and pharmaceutical research units that study antimetabolite mechanisms. It is commonly employed in enzyme activity assays, cell-based studies, and analytical method development where a defined fluoropyrimidine nucleoside is required. Because it is supplied by TCI as a catalogue chemical, it fits routine research workflows in which reproducibility and traceable identity of the compound matter as much as the experiment itself.

Laboratory Applications

Prodrug activation studies — the compound depends on thymidine phosphorylase for conversion, making it a direct model for investigating tissue-dependent enzymatic activation of nucleoside prodrugs in controlled experiments.
Antimetabolite mechanism research — because the activated form interferes with the thymidylate synthesis pathway, it allows researchers to trace how fluoropyrimidines disrupt nucleotide biosynthesis at the biochemical level.
Analytical standard preparation — its defined identity as a fluoropyrimidine nucleoside makes it suitable as a reference substance for chromatographic and spectroscopic method development and system suitability checks.
Enzyme activity assays — thymidine phosphorylase studies can use this substrate to compare conversion rates between sample types, since the enzymatic dependency of the molecule is well characterised.
Structure–activity relationship studies — the 5'-deoxy modification and 5-fluoro substitution provide a defined structural template for comparing uridine derivatives and evaluating how each modification changes biological behaviour.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS Number: 3094-09-5
Catalogue Number: D3579
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Chemical Class: Synthetic fluoropyrimidine nucleoside, uridine derivative (doxifluridine / 5'-DFUR)
Pack Sizes: Available in standard TCI research-scale packaging; please confirm the size required when ordering

Handling and Storage

Store the material in its original tightly closed container, kept in a cool, dry place and protected from light and moisture, following the storage conditions stated on the manufacturer's label and safety data sheet. Amber glass or the supplied original packaging is appropriate, and containers should be resealed promptly after each use to limit exposure to humid air. Handle the solid in a well-ventilated area or fume hood, wearing a laboratory coat, nitrile gloves, and eye protection, and avoid generating dust during weighing or transfer. As a biologically active fluoropyrimidine compound intended for research use only, it should be handled by trained personnel, kept away from food and drink, and disposed of as chemical waste in accordance with institutional and local regulations. Consult the manufacturer's safety data sheet before first use.