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Description
TCI D3648 4,6-Diaminopyrimidine is a simple yet highly useful heterocyclic building block, consisting of a pyrimidine core bearing two amino groups at the 4 and 6 positions. The pyrimidine ring is one of the most important scaffolds in biological chemistry because it forms the basic framework of the nucleic acid bases, and for this reason its derivatives have been extensively studied in drug research and biochemistry. In the laboratory, this compound serves as a starting material for constructing fused heterocyclic systems such as purines and pteridines, as a nitrogen-donor ligand in coordination chemistry, and as a hydrogen-bond-rich molecular recognition component.
The main properties that make this material a preferred choice are its symmetrical substitution pattern and its hydrogen bonding capability. The two equivalent amino groups provide predictable, easily controlled reactivity in acylation, sulfonylation, condensation, and amination reactions, while the combination of ring nitrogen atoms acting as proton acceptors and amino groups acting as proton donors generates recognition motifs comparable to those found in DNA base pairing. These characteristics are exploited in supramolecular chemistry, in the design of metal-organic frameworks, and in the preparation of hydrogen-bonded gels and polymers. The molecular symmetry also simplifies product analysis and interpretation of spectra.
In Indonesian laboratories, this building block is typically used in university and institutional research settings where synthetic organic chemistry, medicinal chemistry, and materials chemistry work is carried out. It suits groups preparing heterocyclic compound libraries, exploring nitrogen-donor ligands for coordination complexes, or developing hydrogen-bonded supramolecular materials. Because the compound is supplied as a defined research chemical from TCI, it is also appropriate for methodology development work and for postgraduate research projects that require a consistent, well-characterised starting material.
Laboratory Applications
- Heterocyclic synthesis: the two reactive amino groups allow annulation and cyclisation routes toward fused systems such as purines and pteridines, making it a direct entry point for building more complex nitrogen heterocycles.
- Medicinal chemistry research: because the pyrimidine core is the framework of the nucleic acid bases, this compound serves as a scaffold for preparing analogues studied in drug discovery and biochemical investigations.
- Coordination chemistry: the ring nitrogen atoms and exocyclic amino groups act as nitrogen donors, so the material can be used to prepare metal complexes and to explore new ligand geometries and binding modes.
- Metal-organic framework design: the symmetrical arrangement of donor sites supports the construction of extended coordination networks, giving predictable connectivity when the compound is combined with metal nodes in framework assembly.
- Supramolecular and polymer chemistry: the donor-acceptor hydrogen bonding motif enables preparation of hydrogen-bonded gels and polymers, and supports molecular recognition studies that mimic DNA base pairing interactions.
Specifications
- Brand: TCI
- Product code: D3648
- CAS number: 2434-56-2
- Chemical name: 4,6-Diaminopyrimidine
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack sizes and physical form: as listed in the current TCI catalogue entry for this product code
- Storage: keep in the tightly closed original container under the conditions stated on the manufacturer label
Handling and Storage
Store the product in its original tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible reagents. Amine-functionalised heterocycles are best protected from prolonged exposure to moisture and air, so containers should be resealed promptly after each use and, where appropriate, kept in a desiccator. Handle the material inside a fume hood, using safety glasses, gloves, and a laboratory coat, and avoid inhalation of dust or direct skin contact. Use clean, dry spatulas and glassware when weighing to prevent cross-contamination. Always consult the manufacturer's Safety Data Sheet before use, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.
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