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Description
3-(Dimethylamino)-1-(2-thienyl)-1-propanol is a heterocyclic building block that combines a thiophene ring, a secondary alcohol, and a tertiary amine side chain within a single, relatively compact molecule. This combination of three functional elements makes it a highly useful intermediate in organic synthesis, particularly in routes toward active pharmaceutical compounds containing an arylpropanolamine framework. In medicinal chemistry research laboratories, a compound of this kind is typically used as a starting point for forming aryl ether bonds, carrying out substitution reactions, or modifying the carbinol center into other derivatives according to the target molecule a researcher intends to reach.
The property that makes this material a preferred choice is the presence of three reactive sites that can be addressed selectively. The hydroxyl group on the benzylic-analogous carbon allows etherification, activation into a leaving group, and controlled oxidation. The tertiary amine provides basic character that is useful for salt formation, purification, and adjustment of solubility behaviour. The thiophene ring, meanwhile, opens up opportunities for further aromatic functionalisation. Together, these features give synthetic chemists a flexible platform that can be steered in several directions from one common starting material.
This material also serves as a racemic form that is frequently used as an analytical reference standard. In Indonesian laboratories, that role makes it relevant both to synthetic work in medicinal chemistry research groups and to method development and verification activities where a racemic comparator is required. It is commonly handled in university research laboratories, pharmaceutical development units, and contract research settings that build and characterise heterocyclic intermediates as part of their routine synthetic and analytical workflows.
Laboratory Applications
Arylpropanolamine synthesis routes: the compound supplies a ready-made propanolamine backbone attached to a heteroaromatic ring, shortening multi-step sequences toward pharmaceutical target frameworks.
Aryl ether bond formation: the secondary hydroxyl group can be etherified or activated as a leaving group, making it a direct entry point for coupling to aromatic partners.
Carbinol center modification: the alcohol function can be oxidised under controlled conditions or converted into other derivatives, letting researchers diversify a single scaffold into several analogues.
Salt formation and purification work: the tertiary amine gives basic character that supports salt preparation, crystallisation-based purification, and deliberate adjustment of solubility during process development.
Analytical reference use: as a racemic material it serves as a comparator in analytical method development and verification, particularly where separation or identification of both enantiomeric forms matters.
Specifications
Brand: TCI (Tokyo Chemical Industry), catalogue code D4009
CAS Number: 13636-02-7
Chemical name: 3-(Dimethylamino)-1-(2-thienyl)-1-propanol
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in standard TCI research-scale packaging; please confirm the pack size required for your application
Storage: keep in the original tightly closed container under the conditions stated on the product label and safety data sheet
Handling and Storage
Store the material in its original tightly closed container, protected from moisture and from direct sunlight, and follow the temperature conditions indicated on the product label and accompanying safety data sheet. Amber glass or the manufacturer's supplied container is suitable for keeping the compound isolated from air and light. Handle the compound in a well-ventilated area or fume hood, wearing safety glasses, gloves, and a laboratory coat, and avoid direct contact with skin and eyes as well as inhalation of vapours. Keep it away from strong oxidising agents and strong acids, and label all transfer vessels clearly. Consult the manufacturer's safety data sheet before first use and dispose of residues and contaminated materials through your institution's chemical waste procedures.
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