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Description
3-(Dimethylamino)-1-(2-thienyl)-1-propanone Hydrochloride is the hydrochloride salt of an amino ketone, the characteristic product of a Mannich reaction between an acetylthiophene derivative, formaldehyde, and dimethylamine. In organic synthesis laboratories, this compound serves as an important intermediate that bridges simple aromatic starting materials and more complex target molecules. Its carbonyl group is ready to be reduced to an alcohol, while the aminopropyl chain is already installed from the outset, allowing researchers to shorten their synthetic sequence and focus directly on controlling the selectivity of the subsequent reaction steps.
The hydrochloride salt form is the main reason this material is so widely chosen. As a salt, the compound exists as a solid that is far easier to weigh, store, and handle than the corresponding free base, which tends to be less stable. Its solubility in water and polar solvents is also improved, which simplifies the preparation of reaction solutions as well as purification steps carried out by recrystallization. In addition, the ketone group adjacent to the thiophene ring provides good reactivity toward a range of reducing agents, including asymmetric reduction methods aimed at controlling stereochemistry.
In Indonesian laboratories, this building block is typically used in university research groups, pharmaceutical chemistry laboratories, and synthetic method development work. It is normally ordered in small research quantities for reaction optimization, reduction studies, and the preparation of downstream intermediates, then stored alongside other moisture-sensitive amine salts. Analytical and synthetic teams generally handle it as part of a broader building-block inventory supporting multi-step organic synthesis programs.
Laboratory Applications
- Mannich product chemistry studies: the compound is a representative Mannich base, making it a practical reference substrate when teaching or investigating aminomethylation reactions on aromatic ketone systems.
- Carbonyl reduction experiments: the ketone adjacent to the thiophene ring is readily reduced to the corresponding amino alcohol, supporting routine hydride reduction work in synthetic laboratories.
- Asymmetric reduction and stereoselectivity research: the activated ketone responds well to chiral reduction methods, making it suitable for screening catalysts and evaluating enantioselectivity outcomes.
- Multi-step synthetic intermediate preparation: the pre-installed dimethylaminopropyl chain shortens synthetic routes toward larger target molecules built from simple aromatic precursors.
- Method development and reaction optimization: the stable, easily weighed salt form gives reproducible starting conditions for solvent screening, temperature studies, and recrystallization-based purification trials.
Specifications
- Brand: TCI
- Product code: D4011
- CAS number: 5424-47-5
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Physical form: solid hydrochloride salt, soluble in water and polar solvents
- Pack sizes: available in standard TCI research pack sizes; please confirm the required quantity when ordering
- Storage: keep in a tightly closed container in a cool, dry place away from moisture
Handling and Storage
Store the material in its original tightly closed container, kept in a cool and dry location away from direct sunlight, heat sources, and humidity, since amine hydrochloride salts readily absorb atmospheric moisture. Amber glass bottles or the supplier's original packaging are suitable, and a desiccator may be used for opened containers. Handle the solid inside a fume hood while wearing safety glasses, a laboratory coat, and chemical-resistant gloves, and avoid generating dust during weighing and transfer. Close containers immediately after use, label all prepared solutions clearly, and dispose of residues and contaminated materials in accordance with your institution's chemical waste procedures.
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