(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol is the single-enantiomer form of a thiophene-based amino alcohol that is widely used as a chiral intermediate in organic synthesis. Unlike its racemic counterpart, this compound already carries a defined configuration at the carbinol centre, which allows researchers to move directly into subsequent synthetic steps without performing an additional resolution. In medicinal chemistry laboratories, access to intermediates with preserved stereochemical purity is decisive, because the biological activity and safety profile of a molecule frequently depend very strongly on the spatial configuration of its atoms.
The principal characteristic that makes this material a preferred choice is its fixed (S) configuration, combined with three functional groups that can be addressed in sequence. The secondary hydroxyl group is ready to be activated for aryl ether bond formation, the tertiary amine makes salt formation straightforward for purification and for adjusting solubility, and the thiophene ring provides a site for further functionalisation. Working with enantiomerically pure starting material shortens the number of synthetic steps, reduces mass loss caused by isomer separation, and keeps the material balance of a research programme more predictable.
In Indonesian laboratories, this intermediate is typically handled in academic and industrial research settings where chiral synthesis routes are being developed or verified, including pharmaceutical research groups, university organic chemistry laboratories, and method development work. It is generally used at bench scale, weighed out for individual reaction sequences rather than bulk processing, and is well suited to laboratories that need a defined stereochemistry starting point for reproducible multi-step synthesis and for supporting analytical reference work.
- Chiral intermediate in multi-step organic synthesis, where the pre-defined (S) configuration at the carbinol centre removes the need for a separate resolution step and shortens the overall route.
- Aryl ether bond formation studies, since the secondary hydroxyl group is readily activated and converted, making this compound a practical substrate for exploring etherification conditions.
- Medicinal chemistry research on stereochemistry-dependent activity, because a single-enantiomer intermediate allows biological activity and safety profiles to be attributed to one defined spatial configuration.
- Salt formation and solubility adjustment experiments, as the tertiary amine group allows straightforward salt preparation for purification, handling, and control of solubility behaviour.
- Thiophene functionalisation chemistry, where the intact thiophene ring provides an additional site for further derivatisation while the other two functional groups remain available for later transformation.
| Brand | TCI |
|---|---|
| CAS number | 132335-44-5 |
| Molecular formula | — |
| Purity | — |
| Category | TCI |
| Pack sizes | available in standard laboratory research pack sizes; please confirm the available packaging when ordering |
| Physical form | — |
| Storage | store according to the manufacturer's stated conditions on the product label and safety data sheet |
- Product code: TCI D4010
- Chemical name: (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
Store this material in its original tightly closed container, in a cool, dry, and well-ventilated area away from direct sunlight, heat sources, and incompatible chemicals, following the storage conditions stated by the manufacturer on the product label and safety data sheet. Use chemically compatible containers and keep them properly labelled. As with any amino alcohol intermediate used in chiral synthesis, handle the material in a fume hood, wear appropriate personal protective equipment including safety glasses, gloves, and a laboratory coat, and avoid inhalation of vapours or dust and contact with skin and eyes. Close containers immediately after weighing to limit exposure to moisture and air, and consult the safety data sheet before use and for disposal guidance.
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