Droxidopa TCI D4235

Description

TCI D4235 Droxidopa (CAS 23651-95-8) is a synthetic amino acid widely recognized in the research community as a direct precursor of norepinephrine, which is why it is frequently referred to as L-DOPS or L-threo-dihydroxyphenylserine. This compound is supplied by TCI as a pharmaceutical research reagent intended for experimental use only, not for therapeutic application in humans. In the laboratory, droxidopa serves as a test substance in investigations of catecholamine biosynthesis pathways, in studies of the enzyme dopa decarboxylase, and as a comparison compound during the development of chromatographic analytical methods. Its availability makes it easier for researchers to prepare standard solutions and positive controls with a clear and traceable chemical identity.

The characteristics that lead researchers to select droxidopa are structural: the molecule combines a catechol group, an amino group, and a carboxylate group within a single framework carrying a defined stereochemical configuration. This combination gives the compound amphoteric behaviour while also allowing it to undergo enzymatic decarboxylation, the reaction that underpins many neurochemical experiments. The catechol group makes the compound responsive to electrochemical detection and to ultraviolet absorption, so it pairs well with both HPLC-UV and HPLC-EC detector configurations. Having all three functional groups present in one defined molecule allows a single reagent to support several different experimental designs.

In Indonesian laboratories, TCI D4235 Droxidopa is typically used within a pharmaceutical research reagent workflow, where the material functions as a reference substance rather than as a therapeutic product. Research groups working on catecholamine pathways, enzyme studies, and chromatographic method development rely on a reagent with clearly stated chemical identity so that standard solutions and positive controls remain traceable across experiments. Its defined identity supports consistent documentation of experimental work carried out for research purposes only.

Laboratory Applications

• Catecholamine biosynthesis pathway studies — droxidopa is a direct precursor of norepinephrine, so it can be introduced as a defined test substance to trace conversion steps within the pathway under experimental conditions.
• Dopa decarboxylase enzyme research — the molecule carries both an amino group and a carboxylate group and undergoes enzymatic decarboxylation, making it a suitable substrate for characterising this enzyme's activity.
• Chromatographic method development — the compound serves as a comparison substance when establishing separation conditions, retention behaviour, and method parameters for catecholamine-related analytes in the laboratory.
• HPLC-UV and HPLC-EC detection work — the catechol group responds to ultraviolet absorption and to electrochemical detection, so a single reagent supports both detector configurations without changing the reference material.
• Standard solution and positive control preparation — a reagent with clear, traceable chemical identity allows researchers to prepare reference solutions and controls that remain consistent and documentable across experiments.

Specifications

• Brand: TCI
• Product code: D4235
• CAS number: 23651-95-8
• Chemical identity: Droxidopa, also known as L-DOPS or L-threo-dihydroxyphenylserine
• Category: Life Science > Biochemicals and Reagents > Pharmaceutical Research Reagents (for Experimental Use)
• Pack sizes: available in the packaging options offered by TCI for this catalogue item; confirm the required size when ordering
• Intended use: research and experimental use only, not for therapeutic use in humans

Handling and Storage

Store TCI D4235 Droxidopa according to the storage conditions stated by TCI on the product label and accompanying documentation, and keep the container tightly closed when not in use. Because the molecule contains a catechol group, it should be protected from unnecessary exposure to air, light, and moisture, and kept in its original tightly sealed container or an equivalent chemically compatible vessel. Handle the reagent in a well-ventilated laboratory area using standard personal protective equipment, including a laboratory coat, gloves, and eye protection. Use clean, dry spatulas and glassware when weighing or transferring material to avoid contamination that could compromise standard solutions and positive controls. Prepare solutions only in the quantities needed for the intended experiments, label all prepared solutions clearly with identity and preparation date, and consult the safety data sheet supplied with the product before first use. This material is intended for experimental use only and must not be used for therapeutic purposes in humans; dispose of residues and contaminated consumables through the laboratory's established chemical waste procedures.