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Description
TCI D4342 5'-Deoxy-5-fluorocytidine is a modified nucleoside that combines a cytosine base fluorinated at the 5 position with a ribose sugar lacking the hydroxyl group at the 5' carbon. The compound occupies an important position in nucleoside chemistry studies because it functions both as a pyrimidine base analogue and as a synthetic precursor within fluoropyrimidine derivative pathways. In the laboratory, this material is used as a reference standard, a synthetic starting material, and a test substance in nucleoside metabolism research. The presence of the fluorine atom alters the electronic behaviour of the pyrimidine ring, so the compound is frequently adopted as a model for understanding how halogen substitution influences enzymatic recognition and the chemical stability of a nucleoside.
The characteristics that make this compound a widely preferred choice are the combination of an exocyclic amino group on the cytosine base, a strong carbon–fluorine bond that is not readily cleaved, and a 5'-deoxy group that blocks the conventional phosphorylation site. Together these features produce a molecule with directed reactivity: further modification is generally aimed at the 2' and 3' hydroxyl groups or at the exocyclic amine, so researchers obtain clear regiochemical control over subsequent synthetic steps. This predictable pattern of reactivity, combined with a well-defined single-compound identity, makes the material dependable for work where the position of chemical change must be known with confidence.
In Indonesian laboratories, this material is typically handled in university research groups, pharmaceutical and organic synthesis laboratories, and analytical facilities that work with nucleoside and fluoropyrimidine chemistry. It is commonly drawn on when a defined nucleoside analogue is needed for method development, for comparison against samples during identification work, or as a building block in multi-step synthetic routes. Because it is supplied as a discrete catalogue compound with a stated CAS identity, it fits routine laboratory documentation and traceability practices without additional characterisation effort.
Laboratory Applications
- Reference standard preparation — the defined single-compound identity and stated CAS number allow this material to serve as a comparison substance during identification and confirmation work on nucleoside samples.
- Synthetic starting material for fluoropyrimidine derivatives — the compound sits directly within fluoropyrimidine derivative pathways, giving chemists an established entry point rather than requiring construction of the fluorinated pyrimidine core from simpler precursors.
- Nucleoside metabolism research — the material is used as a test substance where investigators need a modified nucleoside whose blocked 5' position prevents conventional phosphorylation, isolating other metabolic behaviour for study.
- Studies of halogen substitution effects — because fluorine alters the electronic behaviour of the pyrimidine ring, this compound serves as a model system for examining how halogen substitution affects enzymatic recognition and chemical stability.
- Regioselective derivatisation chemistry — with the 5' position deoxygenated, chemists can direct modification specifically to the 2' and 3' hydroxyl groups or the exocyclic amine, supporting controlled preparation of further nucleoside analogues.
Specifications
- Brand: TCI
- CAS number: 66335-38-4
- Chemical name: 5'-Deoxy-5-fluorocytidine
- Catalogue number: D4342
- Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
Handling and Storage
Store the container tightly closed in a cool, dry place, protected from light and moisture, and follow the storage conditions stated on the manufacturer's label and safety data sheet for this catalogue item. Keep the material in its original supplier container, or transfer it to a clean, chemically compatible, well-sealed vessel that is clearly labelled with the compound name and CAS number. Handle the compound in a well-ventilated area or fume hood, wearing a laboratory coat, safety glasses, and suitable chemical-resistant gloves. Avoid generating dust, avoid contact with skin and eyes, and use clean, dry spatulas when weighing to prevent moisture uptake and cross-contamination. Return the container promptly to its designated storage location after use, and consult the safety data sheet before handling and before disposal of any residues.
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