TCI D4687, CAS 979-02-2, is 16-Dehydropregnenolone Acetate, a steroid compound more commonly referred to as 16-DPA across industry and research settings. The material is a pregnenolone derivative carrying a double bond at the 16 position and an acetate group at the 3-hydroxyl position, giving it the characteristic four-ring steroid framework. In laboratory work and steroid chemistry research, 16-DPA is recognised as one of the most important intermediate materials available, because it sits at the crossroads of synthetic routes leading toward a wide range of more advanced steroids.
The properties that make this compound a frequent choice are the combination of a stable steroid skeleton and directed reactivity at the enone group in the D ring. The Δ16 double bond, positioned adjacent to the ketone group on the side chain, creates a conjugated system that responds readily to nucleophilic addition, epoxidation, selective hydrogenation and Michael-type reactions. Meanwhile, the acetate group at position three acts as a practical protecting group that is easily removed by hydrolysis whenever the free hydroxyl group is required again.
For laboratories in Indonesia working on steroid chemistry, the presence of a well-defined intermediate such as 16-DPA makes it far easier for researchers to study chemical transformations on the steroid framework without having to begin from raw natural-source material. This shortens the route from planning to bench work in academic research groups, synthetic chemistry laboratories and pharmaceutical development units that need a reliable starting point for building more advanced steroid structures.
- Steroid synthesis intermediate work — 16-DPA sits at the crossroads of routes toward more advanced steroids, so it serves as a defined starting point rather than raw natural material.
- Nucleophilic addition studies — the conjugated enone system formed by the Δ16 double bond next to the side-chain ketone responds readily to added nucleophiles under controlled conditions.
- Epoxidation research — the reactive Δ16 double bond in the D ring offers a directed site for epoxidation chemistry while the remaining steroid skeleton stays stable.
- Selective hydrogenation experiments — the conjugated system allows researchers to explore selective reduction at the D-ring enone without disturbing the wider four-ring steroid framework.
- Michael reaction and protecting-group studies — the enone accepts Michael-type additions, and the 3-acetate group can be removed by hydrolysis to restore the free hydroxyl.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 979-02-2 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Steroids |
| Pack sizes | available in standard TCI catalogue pack sizes; please confirm the size required when ordering |
| Physical form | — |
| Storage | store under the conditions stated on the manufacturer label and product documentation |
- Chemical Name: 16-Dehydropregnenolone Acetate (16-DPA)
Store this material in a tightly closed original container, kept cool, dry and away from direct sunlight, following the storage conditions printed on the manufacturer label. Because the acetate group at position three can be cleaved by hydrolysis, containers should be protected from moisture and kept properly sealed between uses. Handle the compound in a well-ventilated area or fume hood, using gloves, safety glasses and a laboratory coat, and avoid generating or inhaling dust when weighing. Use clean, dry spatulas to prevent contamination of the bulk material, keep the compound separated from strong oxidising agents, and always consult the manufacturer Safety Data Sheet before handling and before disposal of residues.
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