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Description
TCI D5920, CAS number 1192027-04-5, is N,N-Dimethyl-N'-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide, a heterocyclic reagent known among oligonucleotide researchers as the DDTT sulfurizing reagent. The molecule carries a 1,2,4-dithiazole ring bearing a thioxo group, which serves as the source of the reactive sulfur atom. In the laboratory, this material acts as a sulfur transfer reagent in solid-phase oligonucleotide synthesis, converting phosphite linkages into phosphorothioates after the coupling step. That role makes it an important component in the preparation of antisense oligonucleotides, aptamers, and a wide range of modified nucleic acid constructs used in biomolecular research.
The property that makes this reagent so widely chosen is its high sulfurization efficiency combined with short reaction times, so synthesis cycles on automated synthesizers remain compact without sacrificing completeness of conversion. The reagent also shows good solution stability in the solvents commonly used in phosphoramidite workflows, which means a prepared solution can be installed on the instrument and drawn upon repeatedly over a normal working period. In addition, its tendency not to generate excessive side reactions helps keep the crude product profile clean, simplifying downstream purification and analysis of the assembled sequence.
In Indonesian laboratories, this reagent is typically found wherever nucleic acid chemistry is practised: university research groups working on molecular biology and medicinal chemistry, institutional biotechnology laboratories, and service units that assemble custom oligonucleotides for internal projects. It is generally ordered as part of a phosphoramidite reagent set alongside coupling and deblocking solutions, and used on automated synthesizers as well as in smaller manual solid-phase preparations where modified backbones are required.
Laboratory Applications
- Solid-phase oligonucleotide synthesis — the reagent transfers sulfur to the phosphite linkage immediately after coupling, converting it cleanly to a phosphorothioate within a short cycle step.
- Antisense oligonucleotide preparation — phosphorothioate backbones are central to antisense constructs, and this reagent installs them with the high conversion efficiency such sequences require throughout every linkage.
- Aptamer synthesis — selected backbone positions can be sulfurized during assembly, allowing researchers to build modified aptamer sequences on the same automated synthesizer platform without additional handling steps.
- Modified nucleic acid construct research — the reagent supports preparation of nucleic acid analogues where phosphorothioate linkages are introduced at defined positions for biomolecular and structural investigations.
- Automated synthesizer workflows — its good solution stability in common phosphoramidite solvents lets a single prepared bottle stay mounted on the instrument and serve repeated synthesis runs.
Specifications
- Brand: TCI
- CAS number: 1192027-04-5
- Chemical name: N,N-Dimethyl-N'-(3-thioxo-3H-1,2,4-dithiazol-5-yl)formimidamide
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Common designation: DDTT sulfurizing reagent
- Pack sizes: available in standard TCI research-scale packaging; please confirm the size required when ordering
- Storage: keep in the closed original container under the conditions stated on the manufacturer label
Handling and Storage
Store the reagent in its original tightly closed container, kept dry and away from moisture, heat, and direct sunlight, and follow the storage conditions printed on the manufacturer label. Keep containers well sealed between uses, as sulfur transfer reagents of this type are best protected from atmospheric humidity. Prepared solutions should be held in clean, dry, chemically compatible amber glass bottles fitted with septum caps when installed on a synthesizer. Handle the material in a well-ventilated fume hood while wearing safety glasses, nitrile gloves, and a laboratory coat. Weigh and dissolve using dry glassware and anhydrous solvents to preserve reactivity. Label all prepared solutions with contents and preparation date, keep the reagent separated from strong oxidizing agents, and dispose of residues and rinse solvents as chemical waste according to your institution's procedures. Consult the manufacturer's safety data sheet before first use.
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