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Description
TCI E1456 2-(2,2,2-Trifluoroethoxy)-1,3,2-dioxaphospholane 2-Oxide, CAS number 67605-68-9, is a five-membered cyclic phosphate compound bearing a trifluoroethoxy group. It belongs to the non-heterocyclic building block family used as an intermediate in organic synthesis and materials chemistry. The dioxaphospholane 2-oxide ring is reactive toward nucleophiles, which makes it a practical entry point for introducing a phosphate group into a target molecule. In the laboratory, this material helps researchers build phosphoester structures, phosphate-based polymers, and fluorinated compounds without having to follow a long synthetic route.
The characteristic that makes this compound attractive is the combination of a strained cyclic ring with the electron-withdrawing trifluoroethoxy group. Ring strain drives ring-opening reactions to proceed relatively easily, while the trifluoroethyl group increases the electrophilicity of the phosphorus atom and serves as a good leaving group. The presence of fluorine atoms also confers additional properties in the form of oxidative resistance and a different interfacial character in the final product, a feature widely exploited in electrochemical and materials research. Together these traits give the chemist predictable reactivity under mild conditions.
In Indonesian laboratories, this reagent is typically handled in university research groups, government research institutes, and industrial R&D units working on organic synthesis, polymer chemistry, and energy materials. It is normally used inside a fume hood on a small preparative scale, where the reactive ring must be protected from ambient moisture. Because it is supplied as a TCI catalogue item, it is usually ordered per experiment and stored centrally with other moisture-sensitive phosphorus reagents.
Laboratory Applications
- Phosphoester synthesis — the strained dioxaphospholane ring opens readily with alcohols and other nucleophiles, giving researchers a direct route to phosphoester linkages without lengthy multi-step protection and deprotection sequences.
- Phosphate-based polymer preparation — ring-opening of the cyclic phosphate allows phosphorus to be incorporated into a polymer backbone, making the reagent useful for laboratories developing phosphorus-containing macromolecular materials.
- Fluorinated compound synthesis — the trifluoroethoxy group provides a convenient way to bring fluorine into a target structure, supporting work where oxidative resistance or altered interfacial behaviour is required.
- Phosphorylation of target molecules — the electron-withdrawing trifluoroethyl group raises the electrophilicity of the phosphorus centre, so nucleophilic attack proceeds efficiently and the trifluoroethoxy fragment departs as a good leaving group.
- Electrochemical and materials research — the fluorine content contributes oxidative stability and distinct interfacial character to the final product, properties frequently explored in laboratories studying energy materials and functional surfaces.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 67605-68-9
- Chemical name: 2-(2,2,2-Trifluoroethoxy)-1,3,2-dioxaphospholane 2-Oxide
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in standard TCI research-scale catalogue pack sizes; please confirm the option required when ordering
- Storage note: store in a tightly closed container, protected from moisture, in accordance with the manufacturer's instructions
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area away from moisture, ignition sources, and incompatible materials, following the storage conditions stated by the manufacturer on the label and safety data sheet. Keep the product in its original supplier container; if transfer is necessary, use clean, dry, chemically compatible glassware with a secure closure. Handle the compound inside a fume hood and wear appropriate personal protective equipment, including safety goggles, gloves, and a laboratory coat. Because the cyclic phosphate ring is reactive toward nucleophiles, avoid contact with water and protic substances during weighing and transfer, and close the container promptly after use. Read the safety data sheet before first use and dispose of residues and contaminated materials through the laboratory's chemical waste procedure.
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