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Description
TCI E1476 Etonogestrel is a synthetic steroid of the progestin class, supplied by TCI within the Life Science portfolio under the biochemicals and reagents category for steroids. The compound is the active metabolite of desogestrel and is widely recognised as the active ingredient in long-acting contraceptive preparations. In the laboratory, however, its role is principally that of a reference material and research substance: it is used to establish identity and assay content in quality-control testing, to develop analytical methods in biological matrices, and to serve as a reference ligand in progesterone receptor studies and molecular endocrinology investigations.
The properties that make this material a preferred choice begin with its molecular architecture. Etonogestrel possesses a rigid gonane steroid skeleton bearing an ethynyl group at position 17 and an exocyclic methylene group at position 11, a combination that confers high affinity for the progesterone receptor. The sharply defined steroid structure gives the compound consistent chromatographic behaviour and a characteristic mass spectrum, two attributes that are indispensable for quantitative analysis at low concentrations. The unsaturated ketone system on the A ring additionally provides adequate ultraviolet absorption for routine detection, allowing straightforward integration into established instrumental workflows.
In Indonesian laboratories, Etonogestrel is typically encountered in pharmaceutical quality-control units, contract analytical laboratories, and academic or institutional research groups working on hormonal preparations. It supports identity confirmation and content determination during batch release testing, underpins method development and validation work for bioanalytical assays, and provides a dependable reference point for receptor-binding and endocrinology research. Because the compound is hormonally active at very low concentrations, it is handled as a potent substance under controlled laboratory conditions.
Laboratory Applications
Identity confirmation in pharmaceutical quality control, where the compound's characteristic retention behaviour and distinctive mass spectrum allow analysts to verify that a test sample genuinely contains Etonogestrel.
Content and assay determination during batch release testing, since the well-defined steroid structure and adequate ultraviolet absorption support reliable quantitation against a reference standard.
Analytical method development for biological matrices, because the compound's consistent chromatographic behaviour makes it a stable anchor when optimising extraction, separation, and detection parameters.
Progesterone receptor binding studies, where its high receptor affinity arising from the ethynyl and exocyclic methylene substituents makes it a suitable reference ligand for comparative binding work.
Molecular endocrinology research, in which the compound serves as a defined progestin reference for investigating hormonal signalling pathways and the behaviour of synthetic progestins in experimental systems.
Specifications
Brand: TCI
CAS number: 54048-10-1
Category: Life Science > Biochemicals and Reagents > Steroids
Product code: E1476
Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the currently listed options when ordering.
Storage: store according to the conditions stated on the manufacturer's label and product documentation.
Handling and Storage
Store Etonogestrel in its original tightly closed container, protected from light, moisture, and elevated temperature, and follow the storage conditions specified on the manufacturer's label and accompanying documentation. Amber glass vials or the supplied original packaging are appropriate containers; transfer only the quantity required for immediate work and reseal promptly. Because the compound is hormonally active at very low concentrations, handle it as a potent substance: weigh and manipulate the powder inside a fume hood or suitable containment enclosure, wear gloves, a laboratory coat, and eye protection, avoid generating dust, and prevent skin contact or inhalation. Clean balances and work surfaces after use, and dispose of residues and contaminated consumables through established chemical waste procedures. Personnel who are pregnant or may become pregnant should observe particular caution in line with institutional safety policy.
