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Description
TCI F0802 3-(4-Fluorophenyl)propionic Acid is a fluorinated building block that combines a benzene ring bearing a fluorine substituent at the para position with a propionic acid side chain. This simple yet versatile structure makes it a frequently chosen starting material in the synthesis of higher-value organic compounds, particularly within the field of medicinal chemistry. The carboxylic acid group at the end of the chain provides a reactive handle that is readily converted into amides, esters, acyl chlorides, alcohols, or ketones, while the fluorine atom on the aromatic ring imparts a distinctive electronic character that cannot be replicated by other substituents.
The principal reason this compound is so widely selected is the influence the fluorine atom exerts on the properties of the final molecule. Fluorine is highly electronegative yet small in size, so it can modulate the acidity, charge distribution, lipophilicity, and metabolic stability of a molecule without introducing meaningful steric hindrance. The propionate chain, with its two bridging carbon atoms, offers conformational flexibility that is useful when a target molecule needs to reach a particular binding pocket, and at the same time serves as a classic precursor for intramolecular Friedel–Crafts cyclisation reactions.
In Indonesian laboratories, this building block is typically encountered in university and institutional research groups working on organic synthesis, in medicinal chemistry programmes exploring fluorinated analogues, and in pharmaceutical and fine chemical development units preparing intermediates on a bench scale. It is used in routine multi-step synthetic work where a reliable, well-characterised fluorinated starting material is required, and it is generally stocked as a standard reagent alongside other aromatic carboxylic acids on the synthesis shelf.
Laboratory Applications
- Medicinal chemistry intermediate synthesis: the para-fluorine substituent lets researchers tune lipophilicity and metabolic stability of candidate molecules while the acid group anchors further elaboration.
- Amide and ester formation: the terminal carboxylic acid is readily activated and coupled, making this a convenient scaffold for building libraries of fluorinated amide or ester derivatives.
- Intramolecular Friedel–Crafts cyclisation: the two-carbon propionate bridge is a classic precursor for ring closure onto the aromatic system, giving access to fused cyclic frameworks.
- Acyl chloride and ketone preparation: conversion of the carboxyl group to an acyl chloride opens straightforward routes to ketones and other carbonyl-containing fluorinated products.
- Structure–activity relationship studies: the compound supplies a defined fluorinated aromatic motif for comparing electronic and conformational effects against non-fluorinated analogues in target molecules.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS number: 459-31-4
- Product code: F0802
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Pack sizes: available in standard TCI research-scale packaging; please confirm the pack size options when ordering
- Storage: keep in a tightly closed container, in a cool, dry, well-ventilated place away from incompatible materials
Handling and Storage
Store the container tightly closed in a cool, dry, and well-ventilated area, protected from direct sunlight, moisture, and sources of ignition. Keep the material in its original manufacturer container or in a chemically compatible, clearly labelled vessel, and reseal promptly after each use to limit moisture uptake and contamination. Handle the compound in a fume hood using appropriate personal protective equipment, including safety goggles, chemical-resistant gloves, and a laboratory coat. As with any carboxylic acid, avoid contact with skin, eyes, and clothing, avoid generating or inhaling dust, and store away from strong bases and strong oxidising agents. Always consult the manufacturer's Safety Data Sheet before use and follow your institution's chemical waste disposal procedures.
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