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Description
TCI F0779 3-(3-Fluorophenyl)propionic Acid is an aliphatic carboxylic acid carrying a three-carbon chain attached to a benzene ring that is fluorinated at the meta position. The compound holds an important place as a building block because it combines a carboxylic acid group that is very easy to modify with a stable fluorinated aromatic ring. In the laboratory, this material is used to insert a phenylpropionate fragment into larger molecules, whether through amide formation, ester formation, or through further transformations that make use of the propionate chain as a flexible linker between fragments.
The property that makes it a frequent choice is the ease with which its carboxylate group can be activated. The carboxylic acid can be activated using standard coupling reagents such as carbodiimides or uronium reagents, or through formation of the acid chloride, so that coupling with amines proceeds efficiently and predictably. The flexible propionate chain provides a defined spacing and a degree of conformational freedom between the aromatic ring and the newly introduced functional group, an aspect that often determines how well a molecule fits its biological target. The fluorine atom at the meta position adds stability to the aromatic ring.
In Indonesian laboratories, this building block is typically encountered in university research groups, pharmaceutical development units, and contract synthesis laboratories that prepare intermediates and analogue series. It is normally ordered in small research quantities for exploratory synthesis rather than in bulk, and is handled alongside other fluorinated building blocks within a general synthetic organic chemistry workflow. Users generally require reliable, consistent material because the compound is committed to multi-step sequences where an early intermediate determines the outcome of the whole route.
Laboratory Applications
Amide bond formation with primary and secondary amines, where the readily activated carboxylic acid group couples efficiently and predictably using standard carbodiimide or uronium coupling reagents.
Ester synthesis for the preparation of protected intermediates or prodrug-style derivatives, exploiting the same accessible carboxylate handle under conventional esterification and acid chloride conditions.
Introduction of fluorinated aromatic fragments into target molecules, since the meta-fluorinated benzene ring is stable and carries into subsequent steps without requiring special protection.
Construction of analogue series in medicinal chemistry programmes, where the flexible three-carbon propionate chain sets the spacing between the aromatic ring and newly attached functional groups.
Preparation of intermediates for multi-step synthetic routes, serving as an early-stage fragment that can be elaborated further through transformations centred on the propionate chain.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 458-45-7
Product Code: F0779
Chemical Name: 3-(3-Fluorophenyl)propionic Acid
Category: Chemistry > Building Blocks > Fluorinated Building Blocks
Packaging: available in standard research-scale pack sizes; please confirm the currently offered sizes when ordering
Storage: store in a tightly closed original container in a cool, dry, well-ventilated place
Handling and Storage
Store the material in its tightly closed original container in a cool, dry and well-ventilated area, away from direct sunlight, moisture and sources of ignition, and separated from strong bases and strong oxidising agents. Glass containers with chemically resistant closures are suitable for transfer and short-term working storage; always return the container to its designated storage location after use. As with any carboxylic acid, handle the compound in a fume hood and wear appropriate personal protective equipment including safety glasses, gloves and a laboratory coat, since the material may cause irritation to skin, eyes and the respiratory tract. Avoid generating dust during weighing, keep the container closed when not in active use to prevent moisture uptake, and consult the manufacturer's Safety Data Sheet before first use for the complete handling, first aid and disposal guidance.
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