2-(p-Tolyl)acetaldehyde, also known as p-methylphenylacetaldehyde, is an organic compound from the aromatic aldehyde group that is widely used as a building block in laboratory chemical synthesis. Its reactive aldehyde group makes it an ideal starting point for a range of reactions, including aldol condensation, reduction, oxidation, and carbon–carbon bond formation. In organic chemistry laboratories, it plays an important role as a precursor for constructing more complex molecules, including pharmaceutical intermediates, active agrochemical ingredients, and aroma molecules. The presence of a toluene ring with a methyl group at the para position gives the compound a distinct electronic character that influences its reactivity and selectivity in reactions.
With quality maintained by a reputable manufacturer such as TCI, this compound is a dependable choice for researchers seeking consistent and reproducible synthesis results. Laboratories select this material because of its distinctive chemical properties and the ease with which it can be handled as an intermediate. The aldehyde group on its side chain is electrophilic, making it readily attacked by nucleophiles and enabling efficient transformation into a wide variety of derivatives. This combination of predictable reactivity, good stability under proper storage, and versatility across different reaction types makes it a preferred building block in both routine and advanced organic synthesis work.
In Indonesian laboratories, this compound is typically used in research institutions, universities, and industrial R&D facilities that conduct organic synthesis and pharmaceutical development. It serves as a convenient intermediate for chemists who need a reliable aromatic aldehyde scaffold to build larger molecules step by step. Because it is supplied through a local laboratory supplier, researchers can obtain this TCI product conveniently and integrate it into standard synthesis workflows, from small-scale method development to pilot studies, supporting consistent and comparable results across different projects.
- Aldol condensation: The electrophilic aldehyde group readily reacts with enolates and other nucleophiles, allowing chemists to build carbon–carbon bonds and extend the molecule into larger, more complex structures with controlled outcomes.
- Pharmaceutical intermediate synthesis: As a versatile aromatic building block, it serves as a starting point for constructing drug-like molecules, where the p-tolyl fragment contributes a useful lipophilic aryl group to the final structure.
- Agrochemical development: Its stable aromatic core and reactive side chain make it suitable for preparing active ingredients used in crop protection, enabling the systematic assembly of functionalized aromatic scaffolds.
- Flavor and fragrance chemistry: Because the compound belongs to the aromatic aldehyde family associated with aroma molecules, it can be used to prepare fragrant derivatives and odor-active intermediates in research settings.
- Reduction and oxidation studies: The aldehyde function can be selectively reduced to the corresponding alcohol or oxidized to the carboxylic acid, making it an excellent model substrate for studying reaction conditions and catalyst performance.
| Brand | TCI (product code T4311) |
|---|---|
| CAS number | 104-09-6 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | — |
| Physical form | — |
| Storage | store as recommended for reactive aldehydes, protected from air and light |
- Chemical name: 2-(p-Tolyl)acetaldehyde (p-methylphenylacetaldehyde)
This compound should be stored under conditions that protect the reactive aldehyde group from degradation. Keep the container tightly closed in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, and incompatible materials such as strong oxidizers. Use containers made of suitable laboratory-grade material and retain the original TCI packaging whenever possible. When handling, wear appropriate personal protective equipment, including chemical-resistant gloves, safety goggles, and a laboratory coat, and work in a fume hood to avoid inhaling vapors. Avoid prolonged contact with skin and eyes, and keep the substance away from open flames and ignition sources. After use, reseal the container immediately and follow local regulations for waste disposal.
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