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Description
TCI C2064 is Tolfenamic Acid, a compound belonging to the fenamate class that is structurally a derivative of N-arylanthranilic acid, carrying methyl and chloro substituents on the aniline ring. Within this catalogue the compound is classified as a biochemical reagent under the enzymes, enzyme inhibitors, and enzyme substrates category, reflecting its well-established role as a cyclooxygenase inhibition test material in pharmacological and biochemical laboratories. It is supplied as a defined research chemical for investigators who require a characterised fenamate structure in their experimental work.
Researchers use it as a comparison compound for evaluating prostaglandin biosynthesis pathways, for testing the selectivity of new drug candidates, and as a standard in the development of analytical methods for drug residues. The characteristics that make it a preferred choice are its clearly defined fenamate structure and its biochemical activity profile, which has been extensively documented in the scientific literature, so that experimental results can be readily compared against previously published data. As an aromatic carboxylic acid, the compound is a solid that is stable at room temperature, dissolves better in organic solvents such as dimethyl sulfoxide or ethanol than in neutral water, and shows increased solubility under basic conditions owing to formation of the carboxylate salt.
In Indonesian laboratories, this material is typically encountered in university pharmacology and biochemistry departments, pharmaceutical research units, and analytical service laboratories. It supports coursework and thesis research on anti-inflammatory mechanisms, serves as a reference substance when validating chromatographic methods, and is used in screening programmes that benchmark novel inhibitor candidates against an established fenamate. Its documented behaviour makes it practical for laboratories that need reproducible, literature-comparable results.
Laboratory Applications
- Cyclooxygenase inhibition assays — the compound's established role as a fenamate-class inhibition test material makes it a dependable positive control for enzyme activity studies.
- Prostaglandin biosynthesis pathway studies — researchers employ it as a comparison compound to probe how the pathway responds to defined fenamate-class intervention in vitro.
- Selectivity screening of new drug candidates — its documented biochemical activity profile provides a stable benchmark against which candidate inhibitors can be ranked meaningfully.
- Analytical method development for drug residues — the well-defined structure allows it to serve as a standard when establishing detection and quantitation procedures.
- Teaching and thesis research in pharmacology — the extensive published literature lets students compare their experimental outcomes directly with previously reported reference data.
Specifications
- Brand: TCI
- CAS number: 13710-19-5
- Chemical name: Tolfenamic Acid
- Category: Life Science > Biochemicals and Reagents > Enzymes, Enzyme Inhibitors, Enzyme Substrates
- Physical form: solid, stable at room temperature
- Pack sizes: available in the pack sizes listed by the manufacturer for this catalogue number
- Storage: store in a tightly closed container in a cool, dry place away from light
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, protected from direct sunlight and away from incompatible materials such as strong bases and strong oxidising agents. Amber glass bottles or the manufacturer's original packaging are suitable, and containers should be resealed promptly after each use to limit moisture uptake. Handle the solid in a fume hood or well-ventilated area, wearing a laboratory coat, safety glasses, and chemical-resistant gloves, and avoid generating or inhaling dust. Prepare stock solutions in dimethyl sulfoxide or ethanol where required, label them clearly with date and concentration, and dispose of residues and contaminated consumables through the laboratory's chemical waste stream in accordance with institutional procedures. Consult the manufacturer's safety data sheet before first use.
