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Description
TCI C2114 2-Chloro-3-methylbenzoic Acid is a substituted benzoic acid carrying a chlorine atom at the two position and a methyl group at the three position of the aromatic ring. The compound belongs to the non-heterocyclic building block family and serves as a versatile starting material in organic synthesis. Its carboxyl group can be converted into esters, amides, acid chlorides, or alcohols, while the chlorine atom provides a separate reaction site for substitution and coupling chemistry. This combination of two functional groups at adjacent positions gives researchers considerable freedom to construct molecules with fairly specific substitution patterns.
The property that makes this material a frequent choice is its distinctive ortho substitution pattern. The proximity of the chlorine atom to the carboxyl group creates steric hindrance that influences both the acidity and the reactivity of the acid function, so the compound is often used to study steric effects in esterification and amidation reactions. The neighbouring methyl group contributes additional electron density to the ring and can potentially be transformed further through oxidation or free-radical halogenation. As a crystalline solid, the material is stable at room temperature, easy to weigh out accurately, and can be purified using standard laboratory techniques.
In Indonesian laboratories, this building block is typically found in university organic chemistry research groups, pharmaceutical and agrochemical development units, and analytical method development work. It is generally used at bench scale for exploratory synthesis, route scouting, and the preparation of intermediates for further study. Because it is supplied as a stable crystalline solid, it fits routine practice in laboratories where materials are stored for extended periods and dispensed in small portions across multiple experiments.
Laboratory Applications
- Organic synthesis intermediate preparation — the carboxyl group converts readily into esters, amides, acid chlorides, or alcohols, giving a single starting material several downstream routes.
- Coupling chemistry substrate — the chlorine atom on the aromatic ring provides a distinct reaction site for substitution and coupling, independent of the carboxyl function.
- Steric effect studies — the ortho chlorine sits next to the carboxyl group, creating hindrance that makes this compound useful for investigating esterification and amidation behaviour.
- Side-chain functionalisation work — the methyl group at the three position can be transformed further through oxidation or free-radical halogenation to extend the molecular framework.
- Specific substitution pattern construction — having two different functional groups at adjacent ring positions lets researchers assemble target molecules with reasonably defined and controlled substitution.
Specifications
- Brand: TCI
- CAS number: 15068-35-6
- Product code: C2114
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Physical form: crystalline solid
- Storage: stable at room temperature; refer to the manufacturer's documentation for pack sizes and detailed storage guidance
Handling and Storage
Store the material in its original tightly closed container in a cool, dry, well-ventilated area away from moisture, direct sunlight, and incompatible substances. Glass containers with chemically resistant closures are suitable for repackaging, and containers should be clearly labelled. Handle the compound inside a fume hood, wearing safety glasses, gloves, and a laboratory coat, since it is an organic acid that may irritate skin, eyes, and the respiratory tract. Avoid generating dust when weighing, close the container promptly after dispensing, and wash hands thoroughly after handling. Always consult the manufacturer's safety data sheet before use.
