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Description
TCI C2925 is 3-Cyano-4-methoxy-2-pyridone, a heterocyclic building block that combines three reactive features on a single pyridinone framework: a nitrile group, a methoxy group, and a 2-pyridone core that exhibits lactam–lactim tautomerism. In the organic synthesis laboratory, a compound of this type serves as a starting material for constructing more complex heterocyclic systems — for example through transformation of the cyano group into an amide, carboxylic acid, amine, or tetrazole, and through substitution at activated positions on the ring. Its role is to shorten the number of synthetic steps a researcher would otherwise have to carry out starting from simpler materials.
What makes this material a preferred choice is its high density of functionality within a small molecule. The 2-pyridone core is well known as a motif that appears frequently in medicinal chemistry because it can act as both a hydrogen bond donor and a hydrogen bond acceptor, which makes it attractive for assembling compound libraries. The nitrile group is versatile as a synthetic branch point, while the methoxy group can modulate the electron density of the ring and, under certain conditions, act as a displaceable group. Taken together, this combination gives chemists considerable freedom to elaborate the scaffold in several directions from one common intermediate.
In Indonesian laboratories, a building block of this kind is typically used in university and institutional organic synthesis groups, in medicinal chemistry and drug discovery research, and in method development work where a defined heterocyclic starting material is needed. It is handled at the bench scale in fume hoods, weighed out for multi-step sequences, and drawn on when a research group wants to reach a target heterocyclic system without first having to prepare the pyridinone core itself.
Laboratory Applications
Heterocyclic scaffold construction — the pyridinone core with its adjacent nitrile provides a preassembled framework that can be cyclized or annulated toward fused ring systems without building the ring from scratch.
Nitrile functional group transformation — the cyano group can be converted into amides, carboxylic acids, amines, or tetrazoles, making a single intermediate serve as the entry point to several distinct product families.
Medicinal chemistry library synthesis — the 2-pyridone motif acts as both hydrogen bond donor and acceptor, a recognized feature in drug-like molecules, so the scaffold suits systematic analogue preparation.
Substitution chemistry at activated positions — the methoxy group modulates ring electron density and can behave as a displaceable group, allowing researchers to introduce new substituents onto the pyridinone ring.
Synthetic route shortening in multi-step work — using this defined building block removes several preparatory steps that would otherwise be required to assemble the functionalized pyridinone from simpler precursors.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 21642-98-8
Product code: C2925
Chemical name: 3-Cyano-4-methoxy-2-pyridone
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes: available in standard research-scale catalogue packs; please confirm the currently listed pack options when ordering
Storage: keep in the original tightly closed container in a cool, dry, well-ventilated place
Handling and Storage
Store the material in its original tightly closed container in a cool, dry and well-ventilated area, away from direct sunlight, moisture and sources of ignition, and separated from strong oxidizing agents and strong bases. Glass or the manufacturer's supplied container is suitable for storage; keep the label intact so the material remains identifiable. Handle in a fume hood using safety glasses, gloves and a laboratory coat, and avoid generating or inhaling dust when weighing. Close the container promptly after use to limit moisture uptake. Consult the manufacturer's Safety Data Sheet before first use, and dispose of residues and contaminated consumables through the laboratory's chemical waste channel rather than the general drain or bin.
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