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Description
TCI D1377 (S)-(+)-2,3-Diaminopropionic Acid Hydrochloride is the hydrochloride salt of a non-proteinogenic amino acid that carries two amino groups, one at the alpha position and one at the beta position, with a defined S configuration. Within the peptide chemistry category, this compound — commonly abbreviated as Dap — serves as a specialised building block for introducing an additional amino group into a peptide chain. The presence of the side-chain amine allows researchers to construct branches, cyclisations, or conjugates that cannot be achieved using the standard protein-forming amino acids alone.
The properties that make this material a preferred choice are its clearly defined stereochemical purity and the dual reactivity of its two amino groups. The hydrochloride salt form is generally more stable and easier to handle as a solid than the corresponding free base, and it dissolves well in the aqueous media commonly used in peptide chemistry. The beta amino group provides an additional attachment point for fluorescent labelling, cross-linking, or the formation of intramolecular amide bridges. A consistent S configuration matters because the biological activity of a peptide depends strongly on the stereochemistry of every residue it contains.
In Indonesia, this material is widely required by laboratories working on peptide synthesis and chemical biology, including university research groups, biochemistry teaching laboratories, and institutional research units. It is typically ordered in small quantities appropriate to bench-scale synthetic work, where a defined single-enantiomer building block is needed rather than a bulk reagent. Reliable supply of this class of specialised amino acid supports method development and reproducible synthetic protocols across research programmes.
Laboratory Applications
Solid-phase peptide synthesis: incorporated as a residue that introduces an extra side-chain amine, giving the chain an additional handle for further chemical modification after assembly.
Branched and cyclic peptide construction: the beta amino group serves as an anchor point for branching or for closing intramolecular amide bridges within a synthesised sequence.
Peptide conjugation chemistry: the free side-chain amine reacts readily with activated esters and other amine-reactive partners, enabling attachment of payloads to a defined position.
Fluorescent labelling of peptides: the additional amino group provides a specific, predictable site for attaching fluorophores without competing with the backbone alpha amino function.
Cross-linking studies in chemical biology: dual amine reactivity supports controlled cross-link formation, useful when investigating peptide structure, conformation, and molecular interactions.
Specifications
Brand: TCI
CAS number: 1482-97-9
Category: Chemistry > Chemical Biology > Peptide Chemistry
Physical form: solid, supplied as the hydrochloride salt
Pack sizes: available in standard research-scale catalogue pack sizes; please confirm the required size when ordering
Storage: store as a dry solid in a tightly closed container, following the manufacturer's stated conditions on the product label
Handling and Storage
Store the material as a dry solid in a tightly closed container, kept in a cool, dry place and protected from moisture, since amino acid hydrochloride salts can absorb water from humid air. Amber glass or the original manufacturer's container with a well-sealed cap is suitable; label all secondary containers clearly. Handle the powder in a fume hood or well-ventilated area to avoid inhaling dust, and wear a laboratory coat, safety glasses, and appropriate gloves. Use clean, dry spatulas to prevent contamination of the stock, allow closed containers to reach room temperature before opening to avoid condensation, and dispose of residues in accordance with institutional chemical waste procedures. Always consult the manufacturer's safety data sheet before use.
