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Description
TCI D2141, bearing CAS number 728-87-0, is 4,4'-Dimethoxybenzhydrol, a secondary diphenyl alcohol in which both aromatic rings carry a methoxy group at the para position. In the laboratory it is recognised as a highly useful non-heterocyclic building block for introducing a protected benzhydryl group into target molecules. Its role at the research bench is to supply a carbinol centre that is ready for activation, allowing organic chemists to form new carbon–carbon and carbon–heteroatom bonds without having to assemble the diphenylmethane framework from scratch.
The principal property that leads researchers to select this material is the relative stability of the benzhydryl cation formed when its hydroxyl group is activated under acidic conditions. The two methoxy groups at the para positions act as electron donors that delocalise the positive charge through resonance, so substitution reactions proceed under far milder conditions than with the unsubstituted analogue. This same characteristic is what has made the dimethoxybenzhydryl group popular as a protecting group that can be removed again with ease. Its solid form allows precise weighing, and it dissolves readily in common organic solvents.
In Indonesian laboratories, this building block is typically handled in university research groups, synthetic and medicinal chemistry laboratories, and industrial R&D units working on organic synthesis. Because it is supplied as a solid, it can be weighed accurately on an analytical balance and dissolved in an organic solvent immediately before use, which suits laboratories that run reactions at millimole scale. Its good solubility in organic solvents makes it straightforward to incorporate into standard bench-scale synthetic procedures.
Laboratory Applications
Benzhydryl group introduction — supplies a ready-made diphenylmethane framework so chemists can attach the benzhydryl unit to a target molecule without building the skeleton step by step from simpler precursors.
Protecting group chemistry — the dimethoxybenzhydryl moiety derived from this alcohol is widely used as a protecting group precisely because it can be installed and later removed again with relative ease.
Carbon–carbon bond formation — the activated carbinol centre generates a stabilised benzhydryl cation that couples with nucleophilic carbon partners, giving access to new carbon–carbon bonds under mild conditions.
Carbon–heteroatom bond formation — the same activated centre reacts with nitrogen, oxygen and other heteroatom nucleophiles, allowing benzhydryl ethers, amines and related derivatives to be prepared conveniently.
Mild acid-mediated substitution studies — the electron-donating para methoxy groups delocalise positive charge by resonance, letting substitution proceed under conditions far gentler than those required by unsubstituted benzhydrol analogues.
Specifications
Brand: TCI
CAS number: 728-87-0
Chemical name: 4,4'-Dimethoxybenzhydrol
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: solid, allowing precise weighing on an analytical balance
Pack sizes: available in the pack sizes listed on this product page
Storage: keep in a tightly closed container as specified on the manufacturer's label
Handling and Storage
Store this product in its original tightly closed container, kept in a cool, dry and well ventilated area away from direct sunlight, moisture and sources of ignition. Follow the storage conditions stated on the manufacturer's label and in the accompanying safety data sheet. Glass bottles with well fitting caps are suitable for the solid material, and the container should be reclosed promptly after each weighing to limit exposure to atmospheric moisture. Handle the compound in a fume hood while wearing a laboratory coat, safety glasses and chemically resistant gloves, and avoid raising dust when transferring the solid. Do not store it alongside strong acids or strong oxidising agents, and dispose of residues and contaminated materials according to the applicable laboratory chemical waste procedures.
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