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Description
TCI D2677 4-(Dimethylamino)butanoic Acid Hydrochloride is a short-chain tertiary amino acid supplied as its hydrochloride salt, classified within the fields of peptide chemistry and chemical biology. The molecule carries a carboxylic acid group at one end and a dimethylamino group at the other, separated by a flexible butyl chain. This combination makes it a versatile reagent for introducing an ionizable tertiary amine group into target molecules, whether through amide bond formation, esterification, or conjugation onto carrier materials.
The property that makes this reagent a preferred choice is its hydrochloride salt character, which renders the compound a stable solid that is easy to weigh accurately and not prone to volatilization in the way that sharply odorous free amines are. The dimethylamino group is weakly basic, so its charge state depends on pH — a property heavily exploited in the design of molecules that must change behaviour between neutral and acidic environments. The four-carbon chain provides sufficient distance between the basic centre and the carboxyl group, allowing amide coupling reactions to proceed without significant interference from the neighbouring amine group.
In Indonesian laboratories, this reagent is widely used in research work within peptide chemistry and chemical biology, where a defined tertiary amine handle needs to be installed on a molecular scaffold. It is typically ordered by university research groups and institutional laboratories that carry out synthesis and conjugation work, and it is handled as a standard fine chemical reagent within routine bench-scale preparative procedures rather than as bulk process material.
Laboratory Applications
Amide coupling and peptide modification, where the free carboxylic acid is activated to attach a tertiary dimethylamino handle onto amine-bearing peptides and molecular scaffolds.
Introduction of ionizable groups into target molecules, since the weakly basic dimethylamino group gives pH-dependent charge behaviour useful for designing pH-responsive molecular systems.
Esterification chemistry, in which the carboxyl terminus is converted to an ester linkage while the tertiary amine at the opposite end remains available for protonation.
Conjugation onto carrier materials, allowing a basic tertiary amine functionality to be tethered to supports and carriers through the reagent's reactive acid group.
Chemical biology building-block work, where the four-carbon spacer separates the basic centre from the reaction site so coupling proceeds with minimal interference from the amine.
Specifications
Brand: TCI
CAS Number: 69954-66-1
Category: Chemistry > Chemical Biology > Peptide Chemistry
Physical form: solid, supplied as the hydrochloride salt
Pack sizes: available in standard TCI catalogue research-scale packaging; please confirm the currently available pack size when ordering
Storage: keep in a tightly closed container in a cool, dry place, protected from moisture
Handling and Storage
Store the reagent in its original tightly closed container in a cool, dry, well-ventilated area, away from moisture and from direct sunlight or heat sources. As a hydrochloride salt it is hygroscopic in character, so containers should be resealed promptly after weighing and allowed to reach ambient temperature before opening to avoid condensation on the solid. Weigh and transfer the material in a fume hood or well-ventilated bench area using clean, dry glass or chemically compatible plastic containers. Wear safety glasses, gloves, and a laboratory coat, avoid generating or inhaling dust, and keep the compound separated from strong bases and strong oxidizing agents. Label all working solutions clearly and consult the manufacturer's safety data sheet before first use.
