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Description
TCI D2690 3-(Dimethylamino)propionic Acid Hydrochloride is a non-heterocyclic building block classified as a beta-amino acid bearing a tertiary amine group, supplied as its hydrochloride salt. The molecule is remarkably compact, consisting only of a three-carbon chain that links a carboxylic acid function to a dimethylamino function. In the laboratory, this compound serves as a practical reagent for introducing a weakly basic tertiary amine group into larger molecules, for example through amide bond formation, or as a source of beta-amino fragments in the construction of heterocyclic scaffolds and bioactive compounds.
The property that makes this material so widely chosen is the stability of the hydrochloride salt form, which presents the compound as a solid without a sharp odour, easy to weigh out, and considerably easier to store than the corresponding free amine. As a beta-amino acid, the compound can behave in interesting ways under certain conditions, including a tendency to undergo retro-Michael type elimination when treated with a strong base — a characteristic that researchers deliberately exploit when designing removable protecting groups or cleavable linkers. Its good solubility in water and polar solvents further supports aqueous-compatible coupling reactions.
In Indonesian laboratories, this building block fits naturally into synthetic organic chemistry and medicinal chemistry work where a short, well-defined amine-bearing fragment is needed. Its solubility in water and polar solvents makes it convenient for aqueous or mixed-solvent coupling procedures commonly run in academic and industrial research settings, while the salt form simplifies routine handling on the open bench and reduces the special precautions normally associated with volatile free amines.
Laboratory Applications
Amide bond formation: the carboxylic acid function couples readily to amines, allowing a weakly basic tertiary amine group to be installed onto a larger molecular framework in a single step.
Beta-amino fragment donor: the compact three-carbon backbone delivers a defined beta-amino unit for building heterocyclic scaffolds without introducing unnecessary structural complexity into the target.
Bioactive compound synthesis: the dimethylamino group is a frequently sought structural motif, making this reagent useful for preparing candidate molecules in medicinal chemistry programmes.
Cleavable linker design: the tendency toward retro-Michael type elimination under strong base allows researchers to build linkers that can be released deliberately at a chosen stage.
Removable protecting group strategies: the same base-mediated elimination behaviour lets chemists design protecting groups whose removal is triggered under controlled basic conditions rather than harsh reagents.
Specifications
Brand: TCI
CAS number: 14788-12-6
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: available in standard TCI research pack sizes; please refer to the current catalogue listing
Physical form: solid, supplied as the hydrochloride salt
Storage: keep in a tightly closed container in a cool, dry place
Handling and Storage
Store the material in its original tightly closed container in a cool, dry area, protected from moisture and away from strong bases, which can promote the retro-Michael type elimination described above. Well-sealed glass or chemically compatible plastic containers are suitable, and containers should be reclosed promptly after each weighing to limit moisture uptake. Handle the solid in a well-ventilated area or fume hood, wearing safety glasses, gloves, and a laboratory coat, and avoid contact with skin, eyes, and clothing as well as inhalation of dust. Weigh out only the quantity required for the intended reaction, keep the working area clean, and consult the manufacturer's safety data sheet before first use and before disposal of any residues.
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