TCI
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Description
TCI B6840 tert-Butyl 3-Bromopropanoate is a compact alkylating reagent that installs a three-carbon propanoate unit while keeping the carboxylic acid masked as a tert-butyl ester. It reacts readily with amines, thiols, phenols, and stabilised carbanions, making it a dependable choice for linker and side-chain construction. The tert-butyl group can later be removed under acidic conditions to reveal the free acid without disturbing base-sensitive functionality. AMI Scientific offers this TCI reagent in 5 g and 25 g packs for both exploratory and repeat-synthesis workflows.
Scientific References
- Mallesha et al. (2012). ChemInform Abstract: An Efficient Synthesis of tert‐Butyl Ethers/Esters of Alcohols/Amino Acids Using Methyl tert‐Butyl Ether.. ChemInform doi:10.1002/chin.201220048
- Marx et al. (2002). Hetero-Cope rearrangement for the synthesis of potassium 5-tert-butyl-2-(tert-butyl-aminoxy)-benzoate, a highly water-soluble stable free radical. Tetrahedron Letters doi:10.1016/s0040-4039(02)00311-8
- Kraehenbuehl et al. (1994). Vapor Pressures of Methyl tert-Butyl Ether, Ethyl tert-Butyl Ether, Isopropyl tert-Butyl Ether, tert-Amyl Methyl Ether, and tert-Amyl Ethyl Ether. Journal of Chemical & Engineering Data doi:10.1021/je00016a026
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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