• [Di-tert-butyl(chloro)phosphine]palladium(II) Dichloride Dimer (CAS 386706-33-8) - TCI D3704 - AMI Scientific
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TCI

CAS 386706-33-8

[Di-tert-butyl(chloro)phosphine]palladium(II) Dichloride Dimer TCI D3704

[Di-tert-butyl(chloro)phosphine]palladium(II) Dichloride Dimer TCI D3704
Rp 4.575.900,00
Rp 4.575.900,00
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Description

TCI D3704 [Di-tert-butyl(chloro)phosphine]palladium(II) Dichloride Dimer is a binuclear palladium(II) complex stabilised by di-tert-butyl(chloro)phosphine ligands and bridging chloride ligands. In the laboratory it serves as a palladium precatalyst for cross-coupling reactions that form carbon–carbon bonds, including Suzuki–Miyaura, Heck, Sonogashira and Negishi couplings. Its role is to supply a palladium source already paired with an electron-rich phosphine ligand in a single container, so that researchers do not need to prepare a separate mixture of metal precursor and free ligand, and reaction outcomes become considerably easier to reproduce from batch to batch.

The characteristics that make this precatalyst a frequent choice are its air stability combined with high catalytic activity. The di-tert-butylphosphine ligand is both strongly electron-rich and very sterically bulky, and this combination accelerates the oxidative addition step on difficult substrates — for example the relatively inert aryl chlorides — while also accelerating the reductive elimination step. The chloride-bridged dimeric form means the complex is obtained as a solid that is far easier to weigh out and store than the corresponding free phosphine, which removes much of the practical difficulty normally associated with handling electron-rich phosphine ligands at the bench.

In Indonesian laboratories this precatalyst is typically used in synthetic organic and organometallic chemistry work at universities, government research institutes and industrial R&D units, where cross-coupling steps are needed to build biaryl and other carbon–carbon linkages. Because it is dispensed as a single air-stable solid, it fits well into laboratories that do not routinely run all operations inside a glovebox, and it reduces the number of separate reagents that must be stocked, weighed and validated for each coupling experiment.

Laboratory Applications

  • Suzuki–Miyaura coupling: supplies palladium already bound to an electron-rich phosphine, giving reproducible biaryl bond formation without preparing a separate metal-and-ligand mixture beforehand.
  • Heck reaction: the bulky, electron-rich di-tert-butylphosphine ligand promotes both oxidative addition and reductive elimination, supporting alkene arylation on demanding substrates.
  • Sonogashira coupling: delivers a well-defined, air-stable palladium precatalyst for carbon–carbon bond formation between terminal alkynes and organic halides in routine synthetic work.
  • Negishi coupling: the single-container precatalyst format keeps the palladium-to-ligand relationship fixed, which makes organozinc cross-coupling results easier to repeat between runs.
  • Activation of inert aryl chlorides: the strongly electron-rich and sterically bulky phosphine ligand accelerates the oxidative addition step that normally limits these difficult coupling substrates.

Specifications

  • Brand: TCI (catalogue number D3704)
  • CAS number: 386706-33-8
  • Category: Chemistry > Catalysis and Inorganic Chemistry > Cross-coupling Reaction using Transition Metal Catalysts [C-C Bond Formation]
  • Pack sizes: supplied in the standard TCI catalogue pack sizes; please confirm the size required when ordering
  • Physical form: solid (chloride-bridged dimeric palladium(II) complex)
  • Storage: store in a tightly closed original container in a cool, dry place away from moisture and heat

Handling and Storage

Keep the material in its original tightly closed container and store it in a cool, dry area, protected from moisture, direct sunlight and sources of heat. Although this precatalyst is air-stable and therefore more convenient than the free phosphine ligand, it should still be weighed and transferred promptly and the container resealed immediately after use to limit exposure to atmospheric moisture. Handle it in a well-ventilated area or fume hood, use a chemically resistant spatula and clean glass or plastic weighing vessels, and wear a laboratory coat, safety glasses and suitable gloves. Avoid generating dust, keep it separated from incompatible reagents, and follow the manufacturer's safety data sheet together with your institution's chemical waste procedures for disposal of residues.

Dokumen Keamanan & Mutu

↓ Unduh SDS / MSDS (PDF resmi TCI)
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