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Description
TCI D4063 2-Amino-4,5-difluorobenzoic Acid is an anthranilic acid derivative that carries two fluorine atoms at positions 4 and 5 of the aromatic ring, together with an amino group and a carboxyl group positioned adjacent to one another. This combination of three functional groups makes it a high-value starting material in laboratories working on organic synthesis, peptide chemistry, and medicinal chemistry. At the researcher's bench, the compound typically serves as a core scaffold for building fused heterocyclic systems such as quinazolines, benzoxazinones, and acridones, or as a unit for introducing a fluorinated aromatic acyl group onto the chain of a target molecule under development.
The characteristic that makes this material a frequent choice is the presence of two fluorine substituents, which significantly alter the electron density distribution of the benzene ring. The electron-withdrawing effect of fluorine lowers the ring electron density, and this in turn influences both the reactivity of the amino group and the acidity of the carboxylate group — an effect researchers often exploit to direct the selectivity of cyclization reactions. In a medicinal chemistry context, replacing hydrogen with fluorine is a classic strategy for tuning lipophilicity and metabolic stability, so the difluorinated framework offered here gives synthetic chemists a ready-made handle for structure–activity work.
In Indonesian laboratories, this material is generally used in university research groups, government research institutes, and industrial R&D units that carry out multi-step organic synthesis. It appears in projects building heterocyclic compound libraries, in peptide chemistry work requiring fluorinated aromatic building blocks, and in medicinal chemistry programmes exploring new analogue series. Because it is supplied as a defined starting material with a specific CAS identity, it fits well into laboratories that need reproducible, traceable reagents for method development and for the preparation of intermediates on a bench scale.
Laboratory Applications
- Synthesis of fused heterocycles — the adjacent amino and carboxyl groups allow direct ring closure into quinazoline, benzoxazinone, and acridone frameworks without additional functionalization steps.
- Peptide chemistry building block — the carboxyl group can be coupled onto a growing chain, introducing a fluorinated aromatic acyl unit into the target molecule under development.
- Medicinal chemistry analogue development — the two fluorine substituents provide a practical route for tuning lipophilicity and metabolic stability across a series of related candidate structures.
- Selective cyclization studies — because fluorine lowers ring electron density and shifts amino group reactivity, this substrate is useful for investigating and directing cyclization selectivity.
- Structure–activity relationship work — the defined difluoro substitution pattern makes it a reliable reference building block when comparing fluorinated and non-fluorinated analogues in the same series.
Specifications
- Brand: TCI
- CAS Number: 83506-93-8
- Product Code: D4063
- Chemical Name: 2-Amino-4,5-difluorobenzoic Acid
- Category: Chemistry > Chemical Biology > Peptide Chemistry
- Pack sizes: available in standard TCI research-scale packaging; please confirm the size options currently offered when ordering
- Storage: keep in the closed original container under the conditions stated on the manufacturer's label
Handling and Storage
Store the material in its original tightly closed container, kept in a cool, dry, and well-ventilated place away from direct sunlight, moisture, and sources of heat or ignition, and follow any specific storage conditions printed on the manufacturer's label. Use chemically compatible glass or amber containers when transferring or preparing subsamples, and label all secondary containers clearly with the substance name and CAS number. Handle the compound in a fume hood while wearing safety glasses, gloves, and a laboratory coat, and avoid generating dust or inhaling airborne particles. Keep it separated from strong bases and strong oxidizing agents, weigh it out promptly, and reseal the container immediately after use to limit moisture uptake. Always consult the manufacturer's Safety Data Sheet before first use and dispose of residues in accordance with your institution's chemical waste procedures.
