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Description
TCI D4110 Di-tert-butyl 3,3'-Iminodipropionate, CAS number 128988-04-5, is a secondary amine compound carrying two propionate chains protected as tert-butyl esters. In the laboratory, this material serves as a branched building block for constructing linker molecules, dendrimers, and conjugate intermediates. Compared with its iminodiacetate analogue, the longer propionate chains introduce additional distance between the nitrogen centre and the protected carboxylate groups, so conformational flexibility and linker length can be tuned to suit the requirements of the molecular design under development.
The property that makes this compound a preferred choice is the combination of a single reactive point, in the form of a secondary amine, with two protected acid groups that can be unmasked simultaneously under mild acidic conditions. The tert-butyl esters are stable towards bases, nucleophiles, and many common reaction conditions, yet they are cleaved by acid without requiring catalytic hydrogenation, making them safe to use alongside functional groups that are sensitive to reduction. Its symmetrical two-branch structure makes the compound practical as a branching node in the assembly of multivalent molecules.
In Indonesian laboratories, this material dissolves readily in common organic solvents, so it is straightforward to incorporate into routine synthetic workflows in university research groups, institutional research centres, and industrial R&D units. It is typically drawn on at the small synthetic scale, where a branched intermediate is needed for stepwise molecular assembly, and it fits comfortably into standard organic synthesis practice without requiring specialised equipment beyond ordinary glassware and solvent handling facilities.
Laboratory Applications
- Linker synthesis — the secondary amine provides one clean attachment point while the two protected propionate arms remain intact until acid deprotection is required.
- Dendrimer construction — the symmetrical two-branch architecture makes this compound a practical branching node for building successive generations of a dendritic framework.
- Conjugate intermediate preparation — the masked carboxylates can be released together under mild acid, giving two coupling handles for attaching payloads or targeting groups.
- Multivalent molecule assembly — the branched structure allows two functional arms to be presented from a single nitrogen centre in a controlled, reproducible manner.
- Spacer length tuning — the longer propionate chains provide greater separation and conformational flexibility than iminodiacetate analogues when molecular geometry must be adjusted.
Specifications
- Brand: TCI
- CAS number: 128988-04-5
- Product code: D4110
- Chemical name: Di-tert-butyl 3,3'-Iminodipropionate
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the currently listed option when ordering
- Storage: store according to the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area, away from heat sources, direct sunlight, and incompatible materials, following the conditions given on the manufacturer's label and safety data sheet. Keep the material in its original supplier packaging or in a suitably resistant, clearly labelled chemical container, since tert-butyl esters should be protected from acidic contamination and from moisture ingress. Handle in a fume hood using appropriate personal protective equipment, including safety glasses, gloves, and a laboratory coat. Avoid contact with skin and eyes and avoid breathing any vapour or dust. Reseal the container promptly after each use, record the opening date, and dispose of residues and contaminated materials in accordance with applicable institutional chemical waste procedures. Always consult the safety data sheet before first use.
