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Description
TCI E0781 7-Ethylcamptothecin is a camptothecin-derived alkaloid that carries an ethyl group at position 7 of the characteristic pentacyclic framework. Classified under biochemicals and reagents in the alkaloid group, this compound serves as an important material in cell biology research, pharmacology, and medicinal chemistry, because camptothecin and its derivatives are well known as inhibitors of the enzyme topoisomerase I. In the laboratory, the material is used both as a test compound in molecular biology experiments and as an intermediate in the synthesis of further camptothecin derivatives.
The characteristics that make this compound a preferred choice are its intact and well-defined camptothecin framework, together with the ethyl substituent at position 7 that acts as an important entry point for subsequent modification. This position is a structural node that has been widely explored in efforts to tune the solubility properties and activity profile of camptothecin derivatives. Because of this dual character, the material bridges synthetic chemistry work and biological activity testing within a single research workflow, allowing a laboratory to prepare analogues and evaluate them without changing starting materials.
In Indonesian laboratories, the material is typically handled as a solid and is generally dissolved in polar organic solvents such as dimethyl sulfoxide to prepare stock solutions for cell-based assays. Its lactone framework needs to be treated carefully during preparation and handling. It is commonly found in university research groups, pharmacology laboratories, and medicinal chemistry units that work on natural-product derivatives and their biological evaluation.
Laboratory Applications
Topoisomerase I inhibition studies: the intact camptothecin framework makes this compound directly relevant to experiments examining how this enzyme class is inhibited in biochemical and cellular systems.
Cell biology test compound: supplied as a defined alkaloid, it can be dissolved in dimethyl sulfoxide to prepare stock solutions for treating cultured cells in molecular biology experiments.
Synthetic intermediate for camptothecin derivatives: the position 7 ethyl substituent provides a defined entry point for chemists preparing further analogues from a consistent, well-characterised starting framework.
Medicinal chemistry structure-activity work: the position 7 structural node has been widely explored for tuning solubility and activity, making this material useful for comparative derivative series.
Pharmacology research reference material: as a recognised camptothecin derivative, it serves researchers who need a defined alkaloid when correlating chemical structure with observed biological activity.
Specifications
Brand: TCI
CAS number: 78287-27-1
Category: Life Science > Biochemicals and Reagents > Alkaloids
Pack sizes: available in standard TCI research packaging; please confirm the size options when ordering
Physical form: solid
Storage note: store according to the manufacturer label and product documentation supplied with the material
Handling and Storage
Store the material in its original tightly closed container, kept in a cool, dry place away from direct light and moisture, and follow the storage conditions stated on the manufacturer label. Because the compound has a lactone framework that requires careful treatment, avoid unnecessary exposure to humidity and prepare solutions only when needed. When preparing stock solutions in dimethyl sulfoxide, work in a fume hood using clean, dry glassware and appropriate solvent-resistant containers. Handle as a biologically active research chemical: wear a laboratory coat, gloves, and eye protection, avoid inhalation of dust when weighing the solid, and label all prepared solutions clearly. Restrict use to trained personnel in a research setting and dispose of residues in accordance with laboratory chemical waste procedures.
