Picrotoxin (Picrotoxinin + Picrotin) TCI C0375

Chemical Identity

Other names: Cocculin (Picrotoxinin + Picrotin)
CAS No.: 124-87-8
PubChem: CID 31304·SID 87565507
Formula: C30H34O13
Molecular weight: 602.59 g/mol
Purity: >94.0%(HPLC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione;(1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6
SMILES: CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
InChIKey: VJKUPQSHOVKBCO-ZTYBEOBUSA-N
MDL: MDL00074824

Rp 1.908.900,00

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Picrotoxin (TCI C0375) is a natural compound obtained from the seeds of the plant *Anamirta cocculus*. The material is an equimolar mixture of two sesquiterpene lactones, picrotoxinin and picrotin. In neuroscience and pharmacology laboratories, picrotoxin is known as a non-competitive antagonist of the GABA-A receptor. It acts by blocking the chloride channel associated with that receptor. This makes picrotoxin one of the classic pharmacological tools for studying synaptic inhibition in the central nervous system, and it remains a standard reference compound in receptor research.

Researchers choose picrotoxin because its mechanism has been studied for a long time and is well documented in the scientific literature. Picrotoxin blocks the flow of chloride ions through the channel instead of competing at the GABA binding site. This helps researchers separate effects on the channel from effects at the agonist site. The picrotoxinin component is known as the most pharmacologically active part of the mixture, while picrotin is much weaker. In more advanced research, picrotoxin is also used to study GABA-rho receptors and certain glycine receptors, which extends its value beyond classic GABA-A work.

In Indonesia, picrotoxin is relevant to pharmacology, physiology, and neuroscience laboratories in faculties of medicine, pharmacy, and biology, as well as research centers studying the nervous system. Typical users include lecturers, graduate students, and research staff who run receptor pharmacology experiments, electrophysiology studies, or teaching practicals on inhibitory neurotransmission. Because it is listed under crude medicine ingredients for research and experimental use, it is intended only for laboratory research and not for human or veterinary use.

TCI brochures (PDF)

Traditional Medicine/Crude Medicine Research Reagents 2024-09-11 · p. 1
Terpenes 2025-09-22 · p. 7
Plant Research Reagents 2026-02-24 · p. 8
Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 25

Related TCI products

GABA-A receptor antagonism studies: picrotoxin blocks the receptor-associated chloride channel non-competitively, so researchers can suppress GABA-A-mediated currents and confirm their role in a given response.
Research on synaptic inhibition in the central nervous system: as a classic pharmacological tool, picrotoxin helps isolate inhibitory components of synaptic transmission and show how inhibition shapes neuronal network activity.
Mechanistic separation of channel and agonist-site effects: because picrotoxin does not compete at the GABA binding site, it lets researchers tell channel-blocking effects apart from effects at the agonist site.
Studies of GABA-rho and certain glycine receptors: in more advanced research, picrotoxin serves as a probe for these related ligand-gated chloride channels, which supports comparative receptor pharmacology work.
Teaching and research in pharmacology and physiology: its long history and extensive documentation in the literature make picrotoxin a dependable reference compound for practicals, theses, and validation of experimental models.

Brand	TCI (product code C0375)
CAS number	124-87-8
Molecular formula	—
Purity	—
Category	Life Science > Biochemicals and Reagents > Crude Medicine Ingredients for Research and Experimental Use
Pack sizes	as listed in the variant options on this page
Physical form	refer to the TCI product label and Safety Data Sheet (SDS) for the batch supplied
Storage	—

Composition: equimolar mixture of picrotoxinin and picrotin, from *Anamirta cocculus* seeds

Store picrotoxin in its original, tightly closed container in a cool, dry, well-ventilated place, protected from light and moisture, and follow the storage conditions on the TCI label and SDS. Keep it apart from food, drinks, and incompatible chemicals, and label clearly any secondary containers used for stock solutions. Picrotoxin is a potent neuroactive compound, so handle it only in a laboratory setting with suitable personal protective equipment, including gloves, a lab coat, and eye protection. Avoid creating or breathing in dust, and weigh the material in a fume hood or ventilated enclosure. Wash your hands after handling, and dispose of waste in line with institutional and local chemical waste regulations. This product is for research use only.

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