TCI C0375 Picrotoxin (CAS 124-87-8) is an equimolar mixture of the natural sesquiterpenoids picrotoxinin and picrotin, classically obtained from *Anamirta cocculus* seeds. It is a well-established GABA-A receptor antagonist that blocks the associated chloride channel, making it a standard pharmacological tool in neuroscience research. Laboratories apply it in brain slice electrophysiology, neuronal culture experiments, and mechanistic comparisons for novel neuroactive compounds. This TCI product is supplied by AMI Scientific in 1 g and 5 g packs strictly for research and experimental use, and it is highly toxic — handle only under trained supervision with full protective equipment.
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