Picrotoxin (Picrotoxinin + Picrotin) TCI C0375

Chemical Identity

Other names: Cocculin (Picrotoxinin + Picrotin)
CAS No.: 124-87-8
PubChem: CID 31304·SID 87565507
Formula: C30H34O13
Molecular weight: 602.59 g/mol
Purity: >94.0%(HPLC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (1R,3R,5S,8S,13R,14S)-1-hydroxy-14-(2-hydroxypropan-2-yl)-13-methyl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6,11-dione;(1R,5S,8S,13R,14R)-1-hydroxy-13-methyl-14-prop-1-en-2-yl-4,7,10-trioxapentacyclo[6.4.1.19,12.03,5.05,13]tetradecane-6
SMILES: CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O
InChIKey: VJKUPQSHOVKBCO-ZTYBEOBUSA-N
MDL: MDL00074824

Rp 1.856.400,00

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TCI C0375 Picrotoxin (CAS 124-87-8) is an equimolar mixture of the natural sesquiterpenoids picrotoxinin and picrotin, classically obtained from *Anamirta cocculus* seeds. It is a well-established GABA-A receptor antagonist that blocks the associated chloride channel, making it a standard pharmacological tool in neuroscience research. Laboratories apply it in brain slice electrophysiology, neuronal culture experiments, and mechanistic comparisons for novel neuroactive compounds. This TCI product is supplied by AMI Scientific in 1 g and 5 g packs strictly for research and experimental use, and it is highly toxic — handle only under trained supervision with full protective equipment.