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Description
Glycine Hydrochloride is the hydrochloride salt of glycine, the simplest amino acid, which has neither a side chain nor a chiral centre. It is supplied by TCI under catalogue number G0103 and carries the CAS number 6000-43-7. In the salt form, the amine group of glycine is protonated, so the compound is acidic when dissolved and produces a solution environment that differs from that of free glycine. Its role in the laboratory is primarily as a building block for acidic buffer solutions, as a starting material for the synthesis of glycine derivatives, and as a reference substance in studies of amino acid acid-base equilibria, a topic routinely taught and investigated in biochemistry.
The properties that make this material a preferred choice are the purity of its solid form, its excellent solubility in water, and its clearly defined protonation behaviour. Because glycine carries two ionisable groups, the ammonium group and the carboxyl group, the hydrochloride salt provides a clean starting point for tracing titration curves and for preparing glycine-HCl buffer systems across the acidic pH range. The absence of a side chain removes both steric and electronic interference, so the data obtained are easier to interpret. The solid form is stable and easy to weigh accurately.
In Indonesian laboratories, this material is typically used in academic and research biochemistry settings where amino acid behaviour is studied directly. It serves teaching laboratories that demonstrate titration and buffer preparation, as well as research groups working on peptide chemistry and chemical biology, where a well-characterised and reliably sourced glycine salt is needed. Its convenient handling makes it suitable for routine bench work and for repeated preparations in a shared laboratory.
Laboratory Applications
Acidic buffer preparation: the protonated amine group makes this salt suitable for building glycine-HCl buffer systems that hold a defined acidic pH range for biochemical work.
Amino acid titration studies: with two ionisable groups, ammonium and carboxyl, it gives a clean, well-defined starting point for tracing complete acid-base titration curves.
Synthesis of glycine derivatives: it serves as a convenient solid starting material in preparative chemistry, being stable, easy to weigh, and readily dissolved before reaction.
Peptide chemistry work: as the simplest amino acid without a side chain, it introduces no steric or electronic interference into reaction schemes being developed or optimised.
Biochemistry teaching and reference use: its clearly defined protonation behaviour makes it a dependable comparison standard for classroom demonstrations of amino acid acid-base equilibria.
Specifications
Brand: TCI, supplied under catalogue number G0103
CAS number: 6000-43-7
Category: Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering
Physical form: solid, with very good solubility in water
Storage: keep in a closed container under the conditions stated on the supplier label
Handling and Storage
Store the material in a tightly closed container in a cool, dry place, protected from moisture and kept away from direct sunlight. The original supplier container is suitable for long-term storage; for working quantities, use clean glass or chemically compatible plastic vessels that can be sealed securely and labelled clearly. Handle the solid in a well-ventilated area or a fume hood to avoid generating and inhaling dust, and wear standard laboratory personal protective equipment, including safety glasses, a laboratory coat, and suitable gloves. Because the compound is acidic in solution, avoid contact with skin and eyes and rinse thoroughly with water if contact occurs. Close the container promptly after weighing to limit moisture uptake, and always consult the supplier safety data sheet before use.
