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Description
TCI G0179 Diethyl L-Glutamate Hydrochloride is the hydrochloride salt form of the diethyl ester of L-glutamic acid, supplied as a white crystalline solid. In this molecule, both carboxyl groups of glutamic acid have been converted into ethyl esters, protecting them from unwanted reactions, while the amino group is bound as a hydrochloride salt so that the material remains stable during storage. This combination makes it a highly useful intermediate in peptide chemistry, because researchers can work directly with the free amino group once it has been neutralised, without first carrying out a separate carboxyl protection step.
The properties that make this material a preferred choice are its preserved L-configuration and the ease with which its reactivity can be controlled. The amino group, held as a salt, is unreactive during storage, yet it can be liberated immediately by adding a mild base such as triethylamine or N,N-diisopropylethylamine directly in the reaction flask. The ethyl esters at the α and γ positions can be hydrolysed back in a controlled manner using aqueous base whenever the free acid groups need to be restored. The salt form also provides good solubility in polar solvents and reduces the tendency of the material to take up moisture.
In Indonesian laboratories, this compound is typically used in university and institutional research groups working on peptide synthesis, chemical biology, and organic methodology. It is generally ordered as a supporting building block for multi-step syntheses, where a stable, storable glutamate derivative with both carboxyl groups already masked saves preparation time. Because the material is stable as a salt at ambient handling temperatures, it suits laboratories that need reliable bench chemicals for teaching, method development, and routine synthetic work.
Laboratory Applications
- Peptide bond formation: the free amino group released after neutralisation can be coupled directly with activated carboxyl partners, while both ester groups remain masked throughout the coupling step.
- Multi-step organic synthesis: serves as a stable, storable glutamate building block that removes the need for a separate carboxyl protection stage before the target sequence is assembled.
- Chemical biology research: provides an L-configured glutamate derivative for preparing modified amino acid analogues and probe molecules where stereochemical integrity of the starting material must be maintained.
- Controlled ester hydrolysis studies: the α and γ ethyl esters can be cleaved back to the free acids with aqueous base, allowing staged deprotection strategies to be developed and compared.
- Solution-phase reaction work: the hydrochloride salt dissolves well in polar solvents, making it convenient for preparing homogeneous reaction mixtures and stock solutions in synthetic laboratories.
Specifications
- Brand: TCI
- CAS number: 1118-89-4
- Category: Chemistry > Chemical Biology > Peptide Chemistry
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the size required when ordering
- Physical form: white crystalline solid
- Storage: keep in a tightly closed container in a cool, dry place away from moisture
Handling and Storage
Store the material in its original tightly closed container in a cool, dry location, protected from moisture and away from direct sunlight. Amber or opaque glass bottles with well-sealing caps are suitable for transferring smaller working quantities, and containers should be resealed promptly after each use to limit exposure to humid air. Handle the solid in a fume hood or well-ventilated area, using gloves, safety glasses, and a laboratory coat, and avoid generating dust during weighing. Use clean, dry spatulas to prevent contamination of the bulk material, and label all secondary containers clearly. Keep the compound separate from strong bases and strong oxidising agents, and follow institutional waste procedures when disposing of residues and rinse solutions.
