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Description
Glycine Methyl Ester Hydrochloride is the hydrochloride salt of the methyl ester of glycine, the simplest amino acid, in which the carboxyl group has been converted into a methyl ester. In peptide chemistry, this material serves as a carboxyl-terminal unit that is already protected, so it can be coupled directly to another amino acid through amide bond formation. The hydrochloride salt form keeps the amino group protonated, which gives a stable solid that is easy to store; the free amine is then released by adding a mild base immediately before the coupling reaction takes place.
The properties that make this reagent a preferred choice are its good storage stability, consistent purity, and the ease with which the protecting group can be removed. The methyl ester can be hydrolysed back to the free acid using dilute base under mild conditions, so other sensitive groups elsewhere in the target molecule are not damaged in the process. Because glycine has no chiral centre, there is no risk of racemisation during coupling, which makes this material a safe choice for the opening steps of building a peptide chain. The solid also dissolves well in water and in polar solvents such as methanol and dimethylformamide, making it straightforward to prepare homogeneous reaction mixtures.
In Indonesian laboratories, this reagent is typically used in university and institutional research groups working on peptide synthesis, medicinal chemistry, and chemical biology, as well as in industrial R&D settings where short peptide sequences or amide-containing intermediates are prepared. It is commonly kept as a standard shelf reagent for synthesis work, since its handling requirements are modest and its behaviour in coupling reactions is predictable enough for routine method development and for teaching-level synthetic exercises.
Laboratory Applications
Peptide chain elongation — supplies a ready-protected carboxyl-terminal residue that can be coupled directly with an incoming amino acid without an additional esterification step beforehand.
Amide bond formation studies — the free amine liberated by mild base reacts cleanly with activated carboxyl partners, making it a dependable substrate for coupling reagent comparisons.
Racemisation-free coupling steps — because glycine carries no chiral centre, this reagent lets chemists build the first residues of a sequence without any stereochemical erosion.
Medicinal chemistry intermediate preparation — the methyl ester can be carried through several synthetic steps and then hydrolysed with dilute base to reveal the free acid.
Solution-phase synthesis in polar media — its good solubility in water, methanol, and dimethylformamide allows homogeneous reaction mixtures that are simple to monitor and work up.
Specifications
Brand: TCI
CAS number: 5680-79-5
Category: Chemistry > Chemical Biology > Peptide Chemistry
Pack sizes: available in standard TCI catalogue pack sizes; please confirm the size required when ordering
Physical form: solid (hydrochloride salt)
Storage: keep in a tightly closed container in a cool, dry place, protected from moisture
Handling and Storage
Store the material in its original tightly closed container in a cool, dry place, away from moisture and direct sunlight. As a hydrochloride salt, the solid is hygroscopic in character and should be weighed out promptly and the container resealed straight away to avoid moisture pickup. Use clean, dry glass or chemically resistant plastic containers for any subaliquots, and label them clearly. Handle the powder in a fume hood or a well-ventilated area, wear gloves, safety glasses, and a laboratory coat, and avoid generating dust or inhaling it. Consult the manufacturer's safety data sheet before first use and follow local institutional waste disposal procedures.
