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Description
TCI H0117 Hexanoyl Chloride is an acid chloride derived from hexanoic acid, and it stands as one of the most dependable acylating reagents in the organic chemistry laboratory. The compound delivers the hexanoyl group in a highly reactive form, allowing acyl transfer to alcohols, amines, thiols, and aromatic rings to proceed rapidly and in high yield. Its role becomes essential whenever a researcher needs to install a six-carbon chain onto a target molecule, whether to construct esters and amides, to modify the lipophilic character of an active compound, or to prepare derivatives for analytical purposes.
High reactivity is the single property that most often determines the selection of Hexanoyl Chloride. The carbon-chlorine bond at the carbonyl group renders the carbon atom strongly electrophilic, so reactions with nucleophiles proceed from low temperature to room temperature without requiring elaborate catalysts. As a consequence, the compound is also extremely sensitive to moisture and will hydrolyse to form hexanoic acid together with corrosive hydrogen chloride gas. For this reason the quality of the reagent and the integrity of the packaging seal become critical factors, and the synthesis-grade quality supplied by TCI provides the consistency that demanding work requires.
In Indonesian laboratories, Hexanoyl Chloride is commonly used in university research groups, organic synthesis laboratories, and industrial research and development units that prepare esters, amides, and derivatised intermediates. Work with this reagent is normally carried out in a fume hood using dried glassware and anhydrous solvents, and bottles are returned promptly to controlled storage after each withdrawal. Chemists in these settings value a reagent whose reactivity is predictable from batch to batch, since acylation steps often sit early in a longer synthetic route.
Laboratory Applications
- Ester synthesis: reaction with alcohols and phenols proceeds smoothly to give hexanoate esters, since the highly electrophilic carbonyl carbon allows the coupling to run at low to ambient temperature without complex catalysts.
- Amide formation: primary and secondary amines are acylated rapidly to the corresponding hexanamides, making this reagent suitable for building amide linkages where a defined six-carbon acyl chain is required.
- Friedel-Crafts acylation: aromatic rings can be acylated to introduce a hexanoyl substituent, providing a direct route to aryl ketones bearing a six-carbon chain for further synthetic elaboration.
- Lipophilicity modification of active compounds: attaching the hexanoyl group alters the lipophilic character of a target molecule, a common strategy when researchers need to tune the physical behaviour of an active structure.
- Preparation of derivatives for analysis: the reagent converts polar functional groups such as alcohols, amines, and thiols into stable hexanoyl derivatives, supporting analytical workflows that require derivatised samples.
Specifications
- Brand: TCI (Tokyo Chemical Industry)
- CAS Number: 142-61-0
- Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
- Grade: synthesis-grade quality, supplied with consistent batch-to-batch performance
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
- Storage: keep tightly sealed in a cool, dry place, protected from moisture
Handling and Storage
Store Hexanoyl Chloride in a cool, dry, well-ventilated area, away from moisture, water, and any aqueous or alcoholic reagents. Keep the container tightly closed in its original sealed bottle, as seal integrity is a critical factor for this reagent; where material is transferred, use dry glassware and consider an inert atmosphere. Handle only inside a fume hood, since contact with moisture liberates corrosive hydrogen chloride gas. Wear chemical-resistant gloves, safety goggles, and a laboratory coat, and avoid inhalation or contact with skin and eyes. Dry all glassware and solvents before use, reseal the bottle immediately after each withdrawal, and return it promptly to controlled storage. Keep away from strong bases and oxidising agents, and ensure that spill control and eyewash facilities are readily accessible.
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