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Description
DL-Homocysteic Acid is the racemic form of homocysteic acid, a sulfonated amino acid whose structure closely resembles glutamic acid but carries a sulfonic acid group in place of the carboxylate group on its side chain. The compound is widely recognized as an excitatory amino acid agonist that acts on glutamate receptors, particularly receptors of the NMDA type. In the TCI catalogue this product carries the code H0158 and is classified as a non-heterocyclic building block, making it a reference item for laboratories that work with excitatory neurotransmitter analogues.
The property that makes this material a preferred choice is its sulfonic acid group, which is strongly negatively charged and fully ionised across the physiological pH range. As a result the compound is highly soluble in water and ready for use in perfusion solutions and neuronal cell experiment media without requiring any organic solvent. That permanent charge also means its interaction with glutamate receptor binding sites is strong and measurable. Because the product is supplied as a racemate, it contains both enantiomers, which suits screening experiments and comparative studies of stereoisomer activity.
In Indonesian laboratories this material is used mainly in neuroscience research, excitotoxicity studies, and electrophysiology experiments on nervous tissue. Its ready water solubility simplifies preparation of working solutions in academic and institutional laboratories where the use of organic solvents is kept to a minimum. As a racemic grade it is also the more accessible option for routine and exploratory work compared with resolving a single enantiomer for every experiment.
Laboratory Applications
Neuroscience research: the compound serves as an excitatory amino acid agonist at glutamate receptors, allowing researchers to probe receptor-mediated signalling in nervous tissue preparations directly.
Excitotoxicity studies: its strong agonist action on NMDA-type receptors makes it a suitable tool for inducing and examining excitotoxic responses in neuronal models.
Electrophysiology experiments: full ionisation at physiological pH gives complete water solubility, so it can be added to perfusion solutions applied to nervous tissue without organic solvent.
Stereoisomer comparison work: as a racemate containing both enantiomers, the material supports comparative studies in which the activity of each stereoisomer is evaluated side by side.
Screening assays: the racemic composition and reliable aqueous handling make this an appropriate starting material for screening experiments across panels of glutamate receptor targets.
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Specifications
Brand: TCI
CAS number: 504-33-6
Catalogue code: H0158
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Physical form: solid sulfonated amino acid, racemic (contains both enantiomers)
Pack sizes: available in the standard catalogue pack sizes offered for this item
Storage: store according to the conditions stated on the manufacturer label
Handling and Storage
Store the container in a cool, dry place away from direct sunlight and sources of heat, following the storage conditions printed on the manufacturer label. Keep the material in its original tightly closed container, or in a clean, chemically compatible and clearly labelled vessel, to prevent moisture uptake by this readily water-soluble solid. Handle the powder inside a fume hood or in a well-ventilated area, and wear a laboratory coat, safety goggles, and suitable gloves when weighing or transferring it. Because the compound is an active excitatory amino acid agonist, avoid inhalation of dust, skin and eye contact, and ingestion. Prepare aqueous working solutions using clean glassware, and consult the manufacturer safety data sheet before use and disposal.
