TCI H0193 4'-Hydroxyacetophenone is an aromatic ketone carrying a hydroxyl group at the para position relative to the acetyl group, a substitution pattern that makes it a highly versatile bifunctional building block in organic synthesis laboratories. The symmetrical para arrangement allows the two functional groups to behave relatively independently of one another, so researchers can modify the phenolic group or the ketone group separately according to the synthetic route they have designed. The compound is widely recognised as an intermediate in preparative routes toward aminophenol derivatives and pharmaceutical compounds, as well as a starting monomer in research on high-performance aromatic polymers such as polyesters and polyethers that require a rigid phenolic framework.
The properties that make this material a preferred choice begin with its physical form: a white to almost white crystalline solid that is straightforward to weigh accurately and convenient to store. It offers good solubility in polar organic solvents including ethanol, methanol, acetone, and ethyl acetate, which simplifies reaction set-up and work-up. The phenolic group is nucleophilic and therefore ready to undergo etherification or acylation, while the acetyl group can be transformed through aldol condensation, the Claisen–Schmidt reaction, Baeyer–Villiger oxidation, or oxime formation. This dual reactivity gives the chemist two independent handles on a single scaffold, making it an economical starting material for many synthetic pathways rather than a single-purpose reagent.
In Indonesian laboratories, 4'-Hydroxyacetophenone is typically used in university and institutional organic synthesis groups, in pharmaceutical research and development work on intermediates, and in polymer research programmes that build aromatic backbones. Its stability as a crystalline solid suits the practical realities of tropical laboratory conditions, where materials are often stored for extended periods between projects, and its predictable solubility behaviour makes it suitable for routine teaching and research-scale preparations alike.
- Pharmaceutical intermediate synthesis — the para-substituted scaffold serves as a precursor in routes toward aminophenol derivatives and related pharmaceutical compounds, where the independent functional groups allow controlled, stepwise elaboration of the target molecule.
- Aromatic polymer research — as a starting monomer for high-performance polyesters and polyethers, the rigid phenolic framework contributes thermal and mechanical stability to the resulting polymer backbone under demanding research conditions.
- Aldol and Claisen–Schmidt condensation chemistry — the reactive acetyl group readily forms chalcone-type products with aromatic aldehydes, making this a standard substrate for constructing extended conjugated systems in the laboratory.
- Etherification and acylation studies — the nucleophilic phenolic hydroxyl is easily converted into ethers or esters, allowing researchers to install protecting groups or introduce new side chains onto the aromatic ring.
- Functional group transformation exercises — Baeyer–Villiger oxidation and oxime formation on the acetyl group make this compound a practical teaching and method-development substrate for demonstrating selective carbonyl chemistry in undergraduate and research settings.
| Brand | TCI (Tokyo Chemical Industry) |
|---|---|
| CAS number | 99-93-4 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Non-Heterocyclic Building Blocks |
| Pack sizes | Available in standard TCI research-scale packaging; please confirm the required size when ordering |
| Physical form | White to almost white crystalline solid |
| Storage | Keep in a tightly closed container, in a cool, dry, and well-ventilated place |
- Catalogue Number: H0193
Store 4'-Hydroxyacetophenone in its original tightly closed container in a cool, dry, well-ventilated area, away from direct sunlight, moisture, and sources of ignition. Amber glass bottles or the supplier's original packaging are suitable, as they protect the crystalline solid from humidity and light during extended storage. Keep the material separated from strong oxidising agents and strong bases. Handle in a fume hood using standard laboratory personal protective equipment: safety goggles, nitrile gloves, and a laboratory coat. Avoid generating or inhaling dust when weighing out the solid, and use a clean, dry spatula to prevent contamination of the bulk material. Reseal the container promptly after each use, and always consult the manufacturer's Safety Data Sheet before first handling.
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