tert-Butyl 7-Oxo-2,6,10-triazaspiro[4.6]undecane-2-carboxylate TCI B6825

TCI B6825 is tert-Butyl 7-Oxo-2,6,10-triazaspiro[4.6]undecane-2-carboxylate, a heterocyclic building block built on a spiro framework that joins a pyrrolidine ring to a seven-membered lactam ring through a single shared quaternary carbon atom. Materials of this kind become the foundation when researchers need a molecular core that is spatially well defined yet remains straightforward to elaborate further. In the synthetic laboratory, this compound immediately supplies three nitrogen centres of differing reactivity, one of which is already protected as a tert-butyl carbamate, so that a functionalisation sequence can be planned cleanly without having to construct the spiro system from far simpler starting materials.

The characteristic that makes it a frequent choice is the rigidity of the spiro framework, which restricts free rotation so that functional groups installed on the scaffold adopt a more predictable orientation. Its high sp3 carbon content confers physicochemical behaviour that is generally more favourable than that of flat aromatic frameworks, particularly in terms of solubility. The lactam group contributes both a hydrogen bond donor and an acceptor, which is useful in molecular design work, while the Boc group serves as a protecting group that can be removed under acidic conditions to release a secondary amine for subsequent coupling, alkylation or reductive amination steps.

In Indonesian laboratories, a building block of this type is typically drawn upon by university research groups and pharmaceutical research units that are assembling compound libraries or exploring new molecular scaffolds. Because the spiro core is laborious to prepare in house, procuring it ready-made shortens a synthetic route considerably and allows the available working time to be directed towards the diversification steps that actually determine the outcome of the study.

• Medicinal chemistry scaffold development, where the rigid three-dimensional spiro core provides a well-defined starting point for exploring new structural space beyond flat aromatic frameworks.
• Compound library synthesis, since the three differentiated nitrogen centres allow several diversification points to be addressed in a planned sequence from one common intermediate.
• Boc deprotection and coupling sequences, because the tert-butyl carbamate can be cleaved under acidic conditions to release a secondary amine ready for amide formation or alkylation.
• Solubility-oriented scaffold replacement studies, given that the high sp3 carbon content generally delivers more favourable physicochemical behaviour than a comparable planar aromatic building block.
• Hydrogen bonding motif design, as the lactam carbonyl and adjacent N-H supply a paired donor and acceptor that can be positioned deliberately within a target molecule.

• Chemical name: tert-Butyl 7-Oxo-2,6,10-triazaspiro[4.6]undecane-2-carboxylate

Store the material in its original tightly closed container in a cool, dry place away from direct sunlight and sources of heat or ignition. Amber glass or the supplier's original packaging is suitable, and containers should be resealed promptly after each use because carbamate-protected amines are best kept away from prolonged moisture exposure. Handle the compound in a fume hood using gloves, safety glasses and a laboratory coat, and weigh it out with clean dry spatulas to avoid cross-contamination. Keep it separated from strong acids, which cleave the Boc group, and from strong oxidising agents. Always consult the manufacturer's safety data sheet before first use, and dispose of residues and contaminated consumables through the laboratory chemical waste stream in line with institutional procedures.

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