3-Chloro-2-fluorobenzoic Acid (CAS 161957-55-7) is an organic chemical compound belonging to the class of halogen-disubstituted benzoic acids, manufactured by TCI (Tokyo Chemical Industry) under product code C2117. In the laboratory, this compound plays an important role as a building block in organic synthesis, especially in the design of drug molecules, agrochemicals, and functional materials. The presence of a chlorine atom at position 3 and a fluorine atom at position 2 of the benzene ring makes the compound highly valuable, because its carboxyl group can be further reacted through esterification, amidation, or coupling reactions, while the halogen substituents allow selective modification through aromatic substitution reactions.
The main property that makes 3-Chloro-2-fluorobenzoic Acid a preferred choice in the laboratory is its halogen combination, which produces distinctive electronic and steric effects. The highly electronegative fluorine atom influences the electron distribution on the aromatic ring, which can improve metabolic stability and lipophilicity in the target molecules derived from this compound. At the same time, the chlorine substituent contributes steric bulk and additional reactivity, while the carboxylic acid group remains readily available for further transformation. Together, these features give researchers a flexible starting material for building more complex molecular frameworks with predictable, tunable behavior in downstream reactions.
In Indonesian laboratories, this compound is typically used in pharmaceutical and agrochemical research, academic organic chemistry teaching, and industrial research and development in the chemical and materials sectors. It is commonly employed as a starting material for constructing more complex molecular frameworks, and its availability through AMI Scientific makes it convenient for local researchers and quality control laboratories. Because it is a well-characterized commercial reagent with a registered CAS number, it also serves as a reliable reference point for reproducible synthesis work and method validation in both academic and industrial settings.
- Medicinal chemistry building block — the carboxyl group readily undergoes esterification, amidation, and coupling reactions, making it a flexible starting point for constructing drug-like molecular frameworks in pharmaceutical research.
- Agrochemical intermediate synthesis — the fluorine atom contributes metabolic stability while the chlorine provides steric control, properties that are highly valued in designing herbicidal and pesticidal compounds.
- Aromatic substitution studies — the halogen substituents direct and activate selective functionalization of the ring, supporting research on regioselective aromatic substitution reactions in teaching and research laboratories.
- Functional material precursors — the bifunctional structure allows derivatization into monomers or ligands used in developing functional polymers, catalysts, and specialty materials for applied research.
- Analytical reference compound — as a well-defined commercial reagent with a known CAS number, it can serve as a reliable standard for method development and calibration in analytical chemistry laboratories.
| Brand | TCI (Tokyo Chemical Industry), product code C2117 |
|---|---|
| CAS number | 161957-55-7 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | standard laboratory pack sizes available; confirm current options with AMI Scientific |
| Physical form | — |
| Storage | keep container tightly closed and store in a cool, dry place, as detailed in Handling and Storage below |
- Product name: 3-Chloro-2-fluorobenzoic Acid
Store the compound in a cool, dry, well-ventilated area away from direct sunlight, heat sources, and incompatible materials. Keep the container tightly closed when not in use and protect it from moisture, since carboxylic acids tend to absorb humidity from the air. Use the original TCI container or a compatible laboratory-grade container made of glass or suitable inert plastic. Always wear appropriate personal protective equipment, including gloves, safety goggles, and a laboratory coat, and handle the compound in a fume hood to avoid inhaling any dust. Avoid contact with skin and eyes, wash hands thoroughly after handling, and follow standard laboratory waste disposal procedures in accordance with local regulations.
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