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Description
TCI C2094 5-Chloro-2-fluorobenzoic Acid is a substituted benzoic acid carrying a fluorine atom at the ortho position and a chlorine atom at the meta position relative to the carboxyl group. This arrangement makes it one of the most widely used fluorinated building blocks in the synthesis of heterocyclic compounds. In the laboratory, a material of this kind serves as a starting material that shortens synthetic routes, because the aromatic framework together with its key functional groups is already available from the outset, allowing researchers to move directly into the transformation steps that form the core of their molecular design.
The property that makes this compound so highly valued is the position of the fluorine atom adjacent to the carboxyl group. The carboxyl group is electron-withdrawing, so the fluorine in the ortho position becomes sufficiently activated to be displaced by nucleophiles, and this reaction represents a shortcut toward anthranilic acid frameworks as well as fused heterocyclic compounds such as quinazolinones and benzoxazoles. Meanwhile, the chlorine atom at the meta position is more inert, so it remains intact and can be exploited in a subsequent cross-coupling step. The carboxylate group itself is readily activated into an acid chloride, an ester, or an amide.
In Indonesian laboratories, this building block is typically used in academic research groups, pharmaceutical development units, and contract synthesis laboratories that construct heterocyclic scaffolds. It suits work where a reliable, well-defined aromatic starting material is needed for multi-step routes, and where the researcher wants the substitution pattern fixed in advance rather than installed through additional preparative steps. It is handled with standard organic synthesis glassware and conventional purification and characterization workflows.
Laboratory Applications
- Nucleophilic aromatic substitution: the ortho-fluorine is activated by the neighbouring electron-withdrawing carboxyl group, so it is displaced cleanly by amines, alkoxides, and other nucleophiles.
- Anthranilic acid synthesis: displacement of the activated ortho-fluorine with nitrogen nucleophiles gives direct access to anthranilic acid frameworks without additional protecting-group manipulation or rearrangement steps.
- Quinazolinone and benzoxazole construction: the compound provides a shortcut into fused heterocyclic scaffolds because both the carboxyl group and the displaceable fluorine are already correctly positioned.
- Cross-coupling chemistry: the meta-chlorine is comparatively inert during earlier transformations, so it survives intact and remains available as a handle for later cross-coupling steps.
- Carboxyl group derivatisation: the carboxylate is readily activated into an acid chloride, ester, or amide, allowing amide bond formation and further elaboration of the aromatic core.
Specifications
- Brand: TCI
- CAS number: 394-30-9
- Category: Chemistry > Building Blocks > Fluorinated Building Blocks
- Product code: C2094
- Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering.
- Storage: store in a tightly closed container in a cool, dry, well-ventilated place, following the manufacturer's stated conditions on the label.
Handling and Storage
Store the material in its original tightly closed container, in a cool, dry, well-ventilated area away from moisture, direct sunlight, and sources of ignition. Keep it separated from strong bases and strong oxidising agents, and follow the storage conditions stated on the manufacturer's label and safety data sheet. Handle the solid in a fume hood, using gloves, safety goggles, and a laboratory coat, and avoid generating dust or inhaling any airborne particles. As a benzoic acid derivative it may irritate skin, eyes, and the respiratory tract, so weigh and transfer it carefully, close the container immediately after use, and wash hands thoroughly afterwards. Dispose of residues and contaminated materials as chemical waste according to the applicable institutional procedures.
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