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Description
TCI C2176 2-(4-Chlorophenyl)-2-methylpropanol is a neopentyl-like primary alcohol that carries a chlorinated aromatic ring at the para position together with a quaternary carbon centre adjacent to the hydroxymethyl group. The material is classified as a non-heterocyclic building block, meaning a molecular construction material used to assemble the skeleton of a target compound step by step in organic synthesis laboratories. Its role in the laboratory is to supply a branched structural motif that is difficult to build directly from simple starting materials, so that researchers can reduce the number of reaction steps and concentrate their attention on the key stage that forms the final product under investigation.
The distinguishing feature that makes this compound a preferred choice is the presence of two geminal methyl groups on the carbon adjacent to the hydroxyl function. The steric hindrance this creates confers additional stability against unwanted elimination and rearrangement reactions, while at the same time producing a characteristic conformational profile in the final molecule. The chlorine substituent at the para position is a moderate electron-withdrawing group and remains available for further transformation through cross-coupling reactions. The combination of a branched framework and a reactive aromatic handle gives synthetic chemists two independent points of control within a single, readily handled reagent.
In Indonesian laboratories, this building block is typically used in university and institutional organic synthesis groups, in medicinal chemistry and materials research programmes, and in method development work where a defined branched intermediate is required. It suits research settings that prepare compounds on a small to moderate scale, where each reagent must be well characterised and reproducible from batch to batch. It is also used in graduate teaching and thesis laboratories that introduce students to multi-step synthetic route planning.
Laboratory Applications
Multi-step organic synthesis: it provides a pre-formed branched carbon skeleton, allowing research groups to shorten a synthetic route and avoid constructing the quaternary centre from simple precursors themselves.
Cross-coupling chemistry: the para-chlorine substituent serves as a reactive aromatic handle for further transformation, letting chemists attach a wide range of new fragments to the existing framework.
Medicinal chemistry exploration: the geminal dimethyl motif imparts a distinctive conformational profile to candidate molecules, which is often sought when researchers investigate structure–activity relationships in a compound series.
Functional group transformation studies: the primary alcohol offers a well-defined reactive site for oxidation, protection, esterification, or substitution, while the neighbouring quaternary carbon resists unwanted rearrangement.
Reference and method development work: as a defined, consistent building block it supports the preparation of intermediates used to develop and validate chromatographic or spectroscopic analytical methods.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 80854-14-4
Chemical name: 2-(4-Chlorophenyl)-2-methylpropanol
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Product code: C2176
Pack sizes: available in the standard research pack sizes supplied by the manufacturer; please confirm the required size when ordering
Storage: keep in the original tightly closed container in a cool, dry, well-ventilated place
Handling and Storage
Store this building block in its original tightly closed container in a cool, dry, and well-ventilated area, away from direct sunlight, heat sources, ignition sources, and strong oxidising agents. Keep the container clearly labelled and return it to storage promptly after use to limit exposure to moisture and air. Handle the material inside a fume hood using appropriate personal protective equipment, including safety glasses, chemical-resistant gloves, and a laboratory coat. Avoid inhalation of vapours and direct contact with skin and eyes. Use clean, dry glassware or compatible transfer equipment when dispensing, and always consult the manufacturer's Safety Data Sheet for the complete handling, first-aid, and disposal instructions before beginning work.
