• 2,5-Difluorophenol (CAS 2713-31-7) - TCI D2036 - AMI Scientific
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TCI

CAS 2713-31-7

2,5-Difluorophenol TCI D2036

2,5-Difluorophenol TCI D2036
Rp 2.244.900,00
Rp 2.244.900,00
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TCI D2036 2,5-Difluorophenol is a fluorinated building block that combines a phenolic hydroxyl group with two fluorine atoms positioned at the 2 and 5 positions of the aromatic ring. The material is used in synthesis laboratories as a starting scaffold for constructing fluorine-containing aromatic compounds, whether in medicinal chemistry research, agrochemical development, or organic electronic materials. The presence of fluorine substantially alters the electronic properties and solubility of a molecule, which makes compounds of this type an important tool when researchers need to adjust the character of a candidate molecule without changing its overall framework.

The properties that make this material a preferred choice lie in the combination of its reactivity and the influence of its substituents. The hydroxyl group can be alkylated, acylated, converted into a triflate, or used as an attachment point in aromatic ether reactions, while the fluorine atoms act as strong electron-withdrawing groups that reduce the electron density of the ring and increase the acidity of the phenol. The 2,5-substitution pattern provides a distinctive steric and electronic environment that is frequently exploited to direct the regioselectivity of subsequent reactions. In addition, the strong carbon–fluorine bond means that the fluorine substituents generally survive through the reaction sequence.

In Indonesian laboratories, this building block is typically employed in university research groups, government research institutes, and industrial R&D units working on organic synthesis. It is generally ordered in small research quantities for multi-step synthetic routes, method development, and the preparation of intermediates that are later characterised and elaborated further. Because it serves as an early-stage scaffold rather than a bulk consumable, it is usually handled on the bench scale within a fume hood as part of a planned synthetic campaign.

  • Medicinal chemistry scaffold preparation — the fluorinated aromatic ring lets researchers tune the electronic character and solubility of candidate molecules without redesigning the underlying molecular framework.
  • Agrochemical intermediate synthesis — the material provides a fluorine-containing aromatic core that can be elaborated through the hydroxyl group into more complex target structures.
  • Organic electronic materials research — fluorine substitution lowers the electron density of the aromatic ring, a property frequently exploited when adjusting the electronic behaviour of organic materials.
  • Aromatic ether and triflate formation — the phenolic hydroxyl serves as a reliable attachment point for alkylation, acylation, or conversion into a triflate leaving group.
  • Regioselective functionalisation studies — the 2,5-substitution pattern creates a distinctive steric and electronic environment that chemists use to direct where subsequent reactions occur.

Brand TCI
CAS number 2713-31-7
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes available in research-scale quantities; please refer to the current catalogue listing for the sizes offered
Physical form —
Storage store in a tightly closed container in a cool, dry, well-ventilated area
  • Product code: D2036

Store the container tightly closed in a cool, dry, and well-ventilated place, away from direct sunlight, heat sources, and incompatible materials such as strong oxidising agents and strong bases. Keep the material in its original supplier container or in a chemically compatible, clearly labelled vessel, and reseal it promptly after each use to limit exposure to air and moisture. Handle the compound inside a fume hood, wearing safety glasses, chemically resistant gloves, and a laboratory coat. As with all phenolic compounds, avoid skin and eye contact and inhalation of dust or vapour, and wash thoroughly after handling. Consult the manufacturer's safety data sheet before use and dispose of residues and contaminated materials through the laboratory's chemical waste stream.

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