TCI D2569 3,5-Difluorophenol is a fluorinated building block carrying two fluorine atoms positioned meta to the phenolic hydroxyl group. The compound occupies an important place in modern organic chemistry research because the introduction of fluorine atoms is a routine strategy for tuning the properties of target molecules. In the laboratory, this material serves as a starting material for constructing aromatic ethers, esters, and fluorinated aromatic frameworks that are subsequently developed into active pharmaceutical ingredient candidates, agrochemical materials, and functional materials such as liquid crystals.
The characteristic that makes this compound attractive is the strong electronic influence exerted by its two fluorine atoms. Fluorine is highly electronegative, so it withdraws electron density from the ring, increasing the acidity of the hydroxyl group and directing substitution reactivity toward particular positions in a predictable manner. The carbon–fluorine bond is also very strong and resistant to metabolism, a principal reason why fluorinated fragments are widely used in drug design to improve metabolic stability and lipophilicity. Because the fluorine atom is small, replacing a hydrogen atom with fluorine does not substantially alter molecular geometry.
In Indonesian laboratories, this material is typically used at research and development scale in synthetic organic chemistry groups, pharmaceutical and agrochemical discovery programmes, and materials science work. It is normally handled at the bench in small quantities as an intermediate: the phenolic hydroxyl group is derivatised through alkylation, acylation, or coupling steps, and the resulting fluorinated intermediate is carried forward through a multi-step route. University research groups and industrial R&D units use it where a defined fluorinated aromatic scaffold is required rather than one prepared in-house.
- Aromatic ether synthesis — the phenolic hydroxyl group is readily alkylated or arylated, giving fluorinated aryl ethers whose electronic character is set by the two meta fluorine substituents.
- Ester preparation — acylation of the hydroxyl group provides fluorinated aromatic esters, useful where the strongly electron-poor ring modifies hydrolytic and electronic behaviour of the resulting product.
- Pharmaceutical intermediate work — the metabolically robust carbon–fluorine bonds make this scaffold valuable for building active compound candidates with improved metabolic stability and adjusted lipophilicity.
- Agrochemical research — fluorinated aromatic frameworks derived from this phenol serve as intermediates in developing agrochemical materials, where fluorine substitution is used to tune molecular properties.
- Liquid crystal and functional materials chemistry — the small fluorine atoms alter electronic properties without significantly changing molecular geometry, a combination sought when designing functional materials.
| Brand | TCI |
|---|---|
| CAS number | 2713-34-0 |
| Molecular formula | — |
| Purity | — |
| Category | Chemistry > Building Blocks > Fluorinated Building Blocks |
| Pack sizes | available in standard TCI research-scale packaging; please confirm the currently listed pack options when ordering |
| Physical form | — |
| Storage | keep in the tightly closed original container under the conditions stated on the manufacturer's label and safety data sheet |
- Chemical name: 3,5-Difluorophenol
Store the product in its tightly closed original container in a cool, dry, well-ventilated place, away from heat, direct sunlight, moisture, and incompatible materials such as strong oxidising agents and strong bases. Follow the storage temperature and any special conditions specified on the manufacturer's label and safety data sheet. Keep the material in chemically compatible glass or the supplier-provided container, and reseal promptly after each use to limit moisture uptake and vapour release. Handle in a fume hood using safety glasses, chemically resistant gloves, and a laboratory coat, since phenolic compounds are corrosive and irritating to skin, eyes, and the respiratory tract. Avoid dust formation and direct contact, wash hands after handling, and dispose of residues and contaminated materials as chemical waste in accordance with institutional and local regulations. Consult the safety data sheet before first use.
—
Produk Terkait
-
2-Bromoresorcinol TCI B5737
Regular price From Rp 1.034.250,00Regular price -
4-Bromo-3-chlorophenol TCI B5816
Regular price From Rp 1.741.950,00Regular price -
4,4'-[2-(4-Bromophenyl)-2-phenylethene-1,1-diyl]diphenol TCI B6579
Regular price Rp 8.589.000,00Regular price -
4-Chloro-m-cresol TCI C0150
Regular price From Rp 680.400,00Regular price -
4-Chloro-o-cresol TCI C0152
Regular price From Rp 1.151.850,00Regular price -
4-Chloro-3,5-dimethylphenol TCI C0161
Regular price From Rp 709.800,00Regular price -
Chlorohydroquinone TCI C0185
Regular price From Rp 1.299.900,00Regular price -
2-Chlorophenol TCI C0241
Regular price From Rp 532.350,00Regular price
![4,4'-[2-(4-Bromophenyl)-2-phenylethene-1,1-diyl]diphenol (CAS 936803-69-9) - TCI B6579 - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510B6579.jpg?v=1768204513&width=533)
