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Description
TCI D2753 1,5-Dimethyl-2-piperidone is a six-membered cyclic lactam classified as a heterocyclic building block. Its core structure consists of a piperidinone ring bearing methyl groups on the nitrogen atom and at the five position of the ring, producing a cyclic tertiary amide that carries no hydrogen on nitrogen. In the laboratory, compounds of this class serve a dual role: as a starting framework for constructing molecules containing the piperidine ring frequently encountered in bioactive compounds, and simultaneously as a polar aprotic medium capable of dissolving a wide range of organic and inorganic reagents in synthetic reactions.
The most notable characteristic of this material is the combination of high polarity with the absence of any dissociable amide hydrogen. Cyclic tertiary amides generally possess good chemical stability, a relatively high boiling point, and broad solvating power, which is why this class of compounds has been widely studied as an alternative to conventional amide solvents in the development of more sustainable chemistry. As a building block, the lactam carbonyl group can be reduced to a cyclic amine, activated for substitution, or exploited in enolate reactions at the alpha position, while the methyl substituents on the ring further shape the reactivity and steric environment available to the chemist.
In Indonesian laboratories, materials of this type are typically handled in university research groups, government research institutes, and industrial R&D units engaged in organic synthesis and medicinal chemistry programmes. They are used both by teams building piperidine-containing target molecules step by step and by groups evaluating polar aprotic reaction media as part of greener process development. Because the compound is a heterocyclic building block rather than a bulk commodity, it is normally ordered in research quantities for defined synthetic campaigns and method development work.
Laboratory Applications
Heterocyclic scaffold construction: the piperidinone ring supplies a ready-made six-membered nitrogen framework, sparing the chemist the multi-step effort of assembling that core from acyclic precursors.
Medicinal chemistry building block work: piperidine rings are frequently encountered in bioactive compounds, so this lactam offers a direct entry point into analogue series built around that privileged ring system.
Reduction to cyclic amines: the lactam carbonyl can be reduced to give the corresponding cyclic amine, making the compound a convenient precursor for substituted piperidine derivatives in synthetic routes.
Alpha-position enolate chemistry: the carbon adjacent to the lactam carbonyl can be deprotonated and functionalised through enolate reactions, allowing controlled introduction of new substituents onto the ring.
Polar aprotic reaction medium studies: its high polarity without a dissociable amide hydrogen suits investigations into replacements for conventional amide solvents in more sustainable chemistry development.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS Number: 86917-58-0
Catalogue Number: D2753
Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack Sizes: research-scale packs as listed in the current TCI catalogue for this catalogue number
Storage: store in a tightly closed container in a cool, dry, well-ventilated area, following the manufacturer's Safety Data Sheet
Handling and Storage
Keep the container tightly closed and store it in a cool, dry, well-ventilated place away from direct sunlight, heat sources, and incompatible reagents such as strong oxidising agents. Original manufacturer packaging is the preferred container; if the material must be transferred, use clean, chemically compatible glassware or approved solvent bottles that are clearly labelled with the compound name and CAS number. Handle inside a functioning fume hood and wear standard personal protective equipment, including safety goggles, a laboratory coat, and chemically resistant gloves. Avoid inhalation of vapour and contact with skin and eyes, close the container promptly after dispensing, and consult the manufacturer's Safety Data Sheet before first use and before any disposal of residues or contaminated materials.
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