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Description
TCI D3584 2'-Deoxyinosine is a purine nucleoside formed from the hypoxanthine base joined to a 2-deoxyribose sugar, and it occupies a special position in nucleic acid chemistry because of its relaxed base-pairing behaviour. In the laboratory this compound is known as a starting material for building "universal base" units within oligonucleotides — residues that can pair with more than one natural base without introducing excessive destabilisation. In addition, 2'-deoxyinosine is the deamination product of 2'-deoxyadenosine, which makes it a key metabolite in studies of purine pathways, adenosine deaminase activity, and mechanisms of DNA damage and repair.
The characteristic that makes this compound dependable is its ability to provide controlled base-pairing ambiguity. When incorporated into degenerate primers, the inosine residue reduces the number of sequence variants that must be synthesised without drastically sacrificing annealing efficiency. From a chemical standpoint, the hydroxyl groups at the 3' and 5' positions provide the customary points for protection chemistry, while the hypoxanthine ring is relatively stable under standard oligonucleotide synthesis conditions. As a crystalline solid, the material is straightforward to handle and dissolves in water, which simplifies preparation of working solutions.
In Indonesian laboratories, 2'-deoxyinosine is typically used in molecular biology and biochemistry work where nucleic acid chemistry is central. It appears in academic research groups, university teaching and research laboratories, and institutional facilities that prepare modified oligonucleotides or investigate purine metabolism. Because the compound serves both as a synthetic building block and as a reference metabolite, it is commonly stocked by groups whose work spans primer design, enzymatic assays, and DNA damage and repair investigations.
Laboratory Applications
Universal base incorporation into oligonucleotides — the relaxed pairing behaviour of the inosine residue lets a single position accommodate more than one natural base without excessive destabilisation of the duplex.
Degenerate primer design — including inosine residues reduces the number of separate sequence variants that must be synthesised, while annealing efficiency is retained rather than drastically compromised.
Adenosine deaminase activity studies — because 2'-deoxyinosine is the deamination product of 2'-deoxyadenosine, it serves as the authentic reference species for following this enzymatic conversion.
Purine pathway metabolism research — as a key metabolite of purine turnover, the compound supports investigations that need a defined nucleoside standard for pathway characterisation work.
DNA damage and repair mechanism investigations — deamination-derived inosine lesions are directly relevant here, so the compound provides the substrate or reference material such mechanistic studies require.
Specifications
Brand: TCI
CAS number: 890-38-0
Catalogue number: D3584
Category: Chemistry > Chemical Biology > Nucleic Acid Chemistry
Physical form: crystalline solid, soluble in water
Pack sizes: available in the pack sizes offered for this catalogue item; please refer to the product listing
Storage: store as directed for the material; see the handling and storage notes below
Handling and Storage
Store 2'-deoxyinosine in its original tightly closed container, kept in a cool, dry, and well-ventilated place away from moisture and direct sunlight. Amber glass or the supplied primary container is suitable for the crystalline solid; aqueous working solutions should be prepared fresh in clean labelled vessels and kept closed when not in use. Weigh and transfer the powder using clean, dry spatulas to avoid contamination and moisture uptake. Handle in a well-ventilated area or fume hood with laboratory gloves, safety glasses, and a laboratory coat, and follow the manufacturer's safety data sheet for the material together with your institution's standard chemical handling procedures. Avoid generating dust during transfer.
