1,2-Difluoro-4,5-dimethoxybenzene TCI D3626

Chemical Identity

Other names: 4,5-Difluoroveratrole
CAS No.: 203059-80-7
PubChem: CID 853175·SID 87560238
Formula: C8H8F2O2
Molecular weight: 174.15 g/mol
Purity: >95.0%(GC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1,2-difluoro-4,5-dimethoxybenzene
SMILES: COC1=CC(=C(C=C1OC)F)F
InChIKey: WWAOVLXLTJXDGS-UHFFFAOYSA-N
MDL: MDL00070789

Rp 1.590.750,00

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TCI D3626 1,2-Difluoro-4,5-dimethoxybenzene is a substituted benzene compound carrying two adjacent fluorine atoms together with two methoxy groups positioned opposite them on the aromatic ring. The compound is classified as a fluorinated building block, meaning its role in the laboratory is to supply a ready-made aromatic framework to chemists who are assembling target molecules. Because this four-group substitution pattern is already established from the outset, researchers can move directly to subsequent functionalization steps without having to carry out fluorination or selective methoxylation reactions that demand special conditions, expensive catalysts, and lengthy purification.

The property that makes this compound a frequent choice is the combination of electron-withdrawing and electron-donating groups on a single ring. The two neighbouring fluorine atoms are electron-withdrawing and activate certain positions toward nucleophilic aromatic substitution, while the two methoxy groups are electron-donating and direct electrophilic reactions to the remaining positions. This clear-cut difference in electronic character within one molecule gives chemists good control over regioselectivity. The methoxy groups can also be opened up to hydroxyl groups when required, adding a further point of flexibility to synthetic planning.

In Indonesian laboratories, a material of this kind is typically used in synthetic and medicinal chemistry research groups at universities, government research institutes, and industrial R&D units that build target molecules step by step. Working from a pre-substituted aromatic core shortens route length and reduces the number of demanding steps a group has to run in-house, which suits laboratories that plan their synthetic work around available equipment and reagent lead times.

TCI brochures (PDF)

Fluorination Reagents, Fluorinated Building Blocks 2026-03-18 · p. 28

Related TCI products

Multi-step organic synthesis — supplies a pre-formed tetra-substituted aromatic core so researchers begin at the functionalization stage instead of building the substitution pattern themselves.
Nucleophilic aromatic substitution studies — the two adjacent electron-withdrawing fluorine atoms activate specific ring positions, making the compound a convenient substrate for controlled displacement chemistry.
Electrophilic substitution work — the electron-donating methoxy groups direct incoming electrophiles to the remaining positions, allowing predictable regiochemical outcomes in method development.
Regioselectivity investigations — having distinctly electron-withdrawing and electron-donating substituents on one ring lets chemists probe and compare competing directing effects within a single molecule.
Preparation of phenolic derivatives — the methoxy groups can be converted to hydroxyl groups when needed, giving access to related structures without redesigning the whole synthetic route.

Brand	TCI
CAS number	203059-80-7
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Fluorinated Building Blocks
Pack sizes	available in the pack sizes listed on the product page; please confirm the required quantity when ordering
Physical form	—
Storage	keep in the closed original container under the conditions stated on the manufacturer's label and safety data sheet

Product code: D3626
Chemical name: 1,2-Difluoro-4,5-dimethoxybenzene

Store the material in its tightly closed original container, in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible chemicals, following the conditions stated on the manufacturer's label and safety data sheet. Chemically resistant, properly labelled containers should be used for any transfer or subdivision, and containers should be reclosed promptly to limit exposure to air and moisture. Handle the compound in a fume hood using safety glasses, gloves, and a laboratory coat. Review the safety data sheet before first use, keep records of receipt and consumption, and dispose of residues and contaminated materials through the laboratory's chemical waste procedures.

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