• Diethyl Chlorooxalacetate (CAS 34034-87-2) - TCI D3635 - AMI Scientific
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TCI

CAS 34034-87-2

Diethyl Chlorooxalacetate TCI D3635

Diethyl Chlorooxalacetate TCI D3635
Rp 2.067.450,00
Rp 2.067.450,00
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TCI D3635 Diethyl Chlorooxalacetate is the diethyl ester of oxalacetic acid carrying a chlorine atom at the alpha position. The compound belongs to the non-heterocyclic building block family and serves in the laboratory as a highly reactive, dual-function reagent. Within a single molecule it presents a keto group, two ester groups, and a chlorine atom that acts as a leaving group, which allows the compound to react with a range of nucleophiles at different points. This combination makes it a reagent of choice for chemists who want to construct heterocyclic rings or multifunctional side chains in the shortest possible number of steps.

The property that gives this compound its high value is the density of its functional groups. The chlorine atom adjacent to the carbonyl group is very readily displaced by nucleophiles, while the keto group can undergo condensation with amines, hydrazines, and active carbon compounds. The two ester groups provide points for hydrolysis, amidation, or subsequent reduction according to the requirements of the synthetic design. This high reactivity, however, also means the compound is sensitive to moisture and to bases, so working with it demands dry solvents and clean, water-free glassware.

In Indonesian laboratories the material is handled in the same way as other moisture-sensitive building blocks used in multi-step organic synthesis. Reactions are set up in dry solvents with clean, thoroughly dried glassware, and the reagent is returned promptly to sealed storage after each use so that the remaining stock keeps its reactivity. Because a single molecule offers several reaction points, chemists typically plan the sequence of transformations in advance before opening the container.

  • Heterocyclic ring construction: the keto group condenses with amines and hydrazines while the adjacent chlorine is displaced, closing rings in a short sequence of steps.
  • Nucleophilic substitution chemistry: the chlorine atom next to the carbonyl group is very readily displaced, letting chemists introduce a chosen nucleophile at a defined position.
  • Multifunctional side-chain assembly: the single molecule carries a keto group, two esters, and a leaving group, allowing several substituents to be installed without additional coupling reagents.
  • Ester-based downstream derivatisation: the two ester groups provide handles for hydrolysis, amidation, or reduction, so the fragment can be adapted to the synthetic design after coupling.
  • General organic synthesis as a dual-function building block: its reactivity at different points shortens routes that would otherwise require separately prepared and purified intermediates.

Brand TCI
CAS number 34034-87-2
Molecular formula —
Purity —
Category Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes available in the packaging options offered by TCI for this catalogue item
Physical form —
Storage keep tightly sealed and protected from moisture
  • Product code: D3635

Store the container tightly closed in a cool, dry place, away from moisture and from any source of alkaline vapour, since the compound is sensitive to both water and bases. Keep it in the original manufacturer packaging or in a comparable well-sealed, chemically compatible container, and return it to storage immediately after dispensing. Handle the reagent in a fume hood using dry solvents and clean, thoroughly dried glassware, and wear standard laboratory personal protective equipment including gloves, safety glasses, and a laboratory coat. Avoid prolonged exposure of the open container to humid air, and label any transferred portions clearly.

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