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Description
TCI D3642 2'-Deoxy-5-fluorocytidine is a nucleoside analogue belonging to the fluorinated pyrimidine class, built from a cytosine base carrying a fluorine substituent at the 5-position joined to a 2'-deoxyribose sugar. As a biochemical reagent, this compound plays an important role in research that examines nucleotide metabolism, DNA replication and methylation, and the mechanisms of action of pyrimidine antimetabolites. Its very close structural resemblance to natural deoxycytidine allows it to be recognised by the enzymes of the nucleoside salvage pathway, so researchers use it to trace and modulate biological processes at both the molecular and the cellular level.
The characteristic that leads researchers to select this compound is the presence of the single fluorine atom on the pyrimidine ring. Fluorine is small yet strongly electronegative, so this substitution alters the electronic properties of the base without meaningfully disturbing base-pairing geometry. As a result, the compound can enter enzymatic pathways much like a natural substrate while behaving differently at certain catalytic steps — a property that is precisely what makes it valuable in enzyme inhibition studies and epigenetic research. The research-grade solid form makes preparation of stock solutions straightforward and reproducible.
In Indonesian laboratories, this reagent is typically used in university and institutional research settings working on molecular biology, biochemistry, and pharmacology, as well as in laboratories studying nucleotide metabolism and epigenetic regulation. The research-grade solid form suits work patterns in which stock solutions are prepared as needed and dispensed into aliquots for repeated experiments, supporting method development, assay optimisation, and comparative studies against natural nucleoside substrates.
Laboratory Applications
Nucleotide metabolism studies — the compound is recognised by nucleoside salvage pathway enzymes, allowing researchers to follow how a deoxycytidine-like substrate is taken up and processed.
DNA methylation and epigenetic research — the 5-fluorine substituent alters the electronic character of the cytosine base while preserving base-pairing geometry, making it useful for probing methylation-related processes.
Enzyme inhibition assays — because the analogue enters enzymatic pathways like a natural substrate yet behaves differently at particular catalytic steps, it serves well in inhibition experiments.
Pyrimidine antimetabolite mechanism studies — as a member of the fluorinated pyrimidine class, it supports investigations into how antimetabolite compounds interfere with normal nucleotide pathways.
DNA replication research — its close structural similarity to natural deoxycytidine lets researchers modulate and trace replication-associated processes at the molecular and cellular level.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 10356-76-0
Chemical name: 2'-Deoxy-5-fluorocytidine
Category: Life Science > Biochemicals and Reagents > Nucleosides, Nucleotides, Oligonucleotides
Physical form: research-grade solid, suitable for preparing stock solutions
Pack sizes: available in standard research quantities; please refer to the current catalogue listing for available options
Handling and Storage
Store this reagent according to the manufacturer's instructions on the product label, keeping the container tightly closed and protected from moisture and light. As a research-grade biochemical solid, it is best kept in its original container or in a clean, chemically compatible, well-sealed glass or plastic vial, and allowed to reach room temperature before opening to reduce condensation on the solid. Prepared stock solutions should be dispensed into aliquots to limit repeated freeze-thaw cycles and handling of the bulk material. Handle in a well-ventilated area using standard laboratory personal protective equipment, including a lab coat, safety glasses, and suitable gloves, and avoid generating or inhaling dust when weighing. Use clean, dry spatulas and labware for transfers to prevent contamination of the remaining material, and consult the manufacturer's Safety Data Sheet before use and for waste disposal guidance.
