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Description
TCI D4065 Disialyloctasaccharide is a complex sialylated oligosaccharide built from eight sugar units, carrying two sialic acid residues at the termini of its chains. Compounds of this type are structural representations of the glycan portions commonly found on glycoproteins, which makes them important reference materials in the field of glycoscience. In the laboratory, this material serves as a structural standard, an enzyme substrate, and a model ligand for studying how carbohydrate-binding proteins recognize branching patterns and the degree of sialylation of sugar chains attached to cell surfaces and to soluble proteins.
The characteristics that give this material its high value are its structural purity and the clear definition of its glycan chain. Branched oligosaccharides bearing two sialic acid residues are very difficult to obtain through routine isolation from natural sources, so the availability of a well-defined material allows researchers to compare mass spectrometry, liquid chromatography, and nuclear magnetic resonance data against a consistent point of reference. The carboxylate groups on the sialic acid residues contribute a negative charge that influences analytical separation behaviour as well as electrostatic interactions with receptors, and for that reason the material is supplied in a form suited to careful handling.
In Indonesian laboratories, this material is typically used in university research groups, biotechnology laboratories, and analytical facilities working on glycan characterization. It is applied where a defined reference glycan is needed to calibrate or verify analytical methods, to confirm the identity of peaks obtained from biological samples, and to support method development for glycoprotein analysis. Because it is supplied as a defined compound from TCI, it fits work that requires reproducible results across repeated experiments and across different instruments.
Laboratory Applications
Structural reference standard for glycan analysis, providing a defined disialylated octasaccharide against which mass spectrometry, liquid chromatography, and NMR data from unknown samples can be consistently compared.
Enzyme substrate studies, where the defined eight-sugar chain with two terminal sialic acid residues allows sialidase and glycosidase activity to be followed against a structurally unambiguous starting material.
Lectin and carbohydrate-binding protein research, serving as a model ligand for examining how binding proteins recognize chain branching patterns and the degree of sialylation on glycan structures.
Analytical method development, since the negatively charged carboxylate groups of the sialic acid residues make this compound useful for evaluating separation behaviour in chromatographic and electrophoretic systems.
Glycoprotein glycan characterization work, where this compound represents the glycan portions commonly found on glycoproteins and supports the identification of comparable structures released from cell surfaces or soluble proteins.
Specifications
Brand: TCI
CAS Number: 58902-60-6
Product Code: D4065
Product Name: Disialyloctasaccharide
Category: Chemistry > Chemical Biology > Glycoscience
Pack Sizes: available in research-scale pack sizes; please confirm the currently offered packaging when ordering
Storage: store according to the conditions stated by TCI on the product label and accompanying documentation
Handling and Storage
Store this material under the conditions specified by the manufacturer on the product label and in the accompanying documentation, and follow those instructions rather than general assumptions. Keep the container tightly closed and protected from moisture, since sialylated oligosaccharides are hygroscopic in character and readily take up water from the surrounding air. Use clean, dry, tightly sealing containers, and where solutions are prepared, use appropriate vials that limit evaporation and contamination. Weigh and transfer the material with clean spatulas and dry glassware to avoid cross-contamination that would compromise its value as a reference standard. Handle the compound in a well-ventilated area, wear a laboratory coat, gloves, and safety glasses, and avoid generating dust during weighing. Minimize repeated warming and cooling cycles of the stock container, and consult the safety data sheet supplied with the product before use.
